HCSGD entry for CHKA
1. General information
| Official gene symbol | CHKA |
|---|---|
| Entrez ID | 1119 |
| Gene full name | choline kinase alpha |
| Other gene symbols | CHK CK CKI EK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004103 | Choline kinase activity | IDA | molecular_function |
| GO:0004104 | Cholinesterase activity | IEA | molecular_function |
| GO:0004305 | Ethanolamine kinase activity | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006646 | Phosphatidylethanolamine biosynthetic process | IDA IEA TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | IDA TAS | biological_process |
| GO:0006657 | CDP-choline pathway | IDA TAS | biological_process |
| GO:0006869 | Lipid transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008144 | Drug binding | IDA | molecular_function |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0019695 | Choline metabolic process | IEA | biological_process |
| GO:0033265 | Choline binding | IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | IEA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3041336119 | 0.5171939364 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2911759044 |
| GSE13712_SHEAR | Down | -0.2944579427 |
| GSE13712_STATIC | Down | -0.2715411345 |
| GSE19018 | Down | -0.0241976527 |
| GSE19899_A1 | Down | -0.1403928892 |
| GSE19899_A2 | Up | 0.1293974676 |
| PubMed_21979375_A1 | Up | 0.4171643881 |
| PubMed_21979375_A2 | Down | -0.0429519838 |
| GSE35957 | Down | -0.7657479027 |
| GSE36640 | Down | -0.5508175205 |
| GSE54402 | Up | 0.1213336019 |
| GSE9593 | Down | -0.0159940686 |
| GSE43922 | Up | 0.0467635690 |
| GSE24585 | Up | 0.2707622991 |
| GSE37065 | Up | 0.2943857398 |
| GSE28863_A1 | Up | 0.0760730729 |
| GSE28863_A2 | Up | 0.5771686844 |
| GSE28863_A3 | Down | -0.1552326459 |
| GSE28863_A4 | Up | 0.0240263459 |
| GSE48662 | Up | 0.0504608022 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23466301 | Senescence suppresses development of tumors by regulating aging factors, such as cyclin dependent kinase inhibitor (CKI) and telomerase |
| 19486941 | A number of studies suggest that interactions of ROS with the G1 CDK/CKI network play a fundamental role in senescence, which is considered a barrier to tumorigenesis |
| 16234365 | Hematopoietic exhaustion appears to be accelerated in the absence of p21(Cip1/Waf1) (p21), a cyclin-dependent kinase inhibitor (CKI) in irradiated hosts |
| 11389930 | In addition, at the end of their lifespans, the T cell clones did not display the CKI phenotype reported for senescent cells (an increase in p16 and p21 levels) |
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