HCSGD entry for RIPK3

1. General information

Official gene symbolRIPK3
Entrez ID11035
Gene full namereceptor-interacting serine-threonine kinase 3
Other gene symbolsRIP3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001914Regulation of T cell mediated cytotoxicityISSbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002819Regulation of adaptive immune responseISSbiological_process
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004672Protein kinase activityIDA IMPmolecular_function
GO:0004674Protein serine/threonine kinase activityISSmolecular_function
GO:0004704NF-kappaB-inducing kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0010922Positive regulation of phosphatase activityIMPbiological_process
GO:0032147Activation of protein kinase activityIMPbiological_process
GO:0032403Protein complex bindingIMPmolecular_function
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032649Regulation of interferon-gamma productionISSbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043029T cell homeostasisISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046006Regulation of activated T cell proliferationISSbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048535Lymph node developmentISSbiological_process
GO:0048536Spleen developmentISSbiological_process
GO:0048538Thymus developmentISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051291Protein heterooligomerizationIMPbiological_process
GO:0060545Positive regulation of necroptotic processIDA IMPbiological_process
GO:0070235Regulation of activation-induced cell death of T cellsISSbiological_process
GO:0070266Necroptotic processIMPbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:1990000Amyloid fibril formationIMPbiological_process
GO:2000452Regulation of CD8-positive, alpha-beta cytotoxic T cell extravasationISSbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07694559100.80748973820.58601993631.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0245855692
GSE13712_SHEARUp0.1383231995
GSE13712_STATICUp0.4597737317
GSE19018Up0.1243233580
GSE19899_A1Up0.0438895708
GSE19899_A2Up0.0047942773
PubMed_21979375_A1Up0.5815668506
PubMed_21979375_A2Down-0.0418284016
GSE35957Up0.2440690495
GSE36640Up0.0162184590
GSE54402Down-0.0189610861
GSE9593Down-0.0715097615
GSE43922Up0.0135810958
GSE24585Up0.1728063739
GSE37065Up0.3245459874
GSE28863_A1Down-0.1826967929
GSE28863_A2Up0.8752346740
GSE28863_A3Down-0.4489497802
GSE28863_A4Up0.3424504453
GSE48662Up0.1820066540

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.