HCSGD entry for RIPK3

1. General information

Official gene symbol	RIPK3
Entrez ID	11035
Gene full name	receptor-interacting serine-threonine kinase 3
Other gene symbols	RIP3
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001914	Regulation of T cell mediated cytotoxicity	ISS	biological_process
GO:0002224	Toll-like receptor signaling pathway	TAS	biological_process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	biological_process
GO:0002819	Regulation of adaptive immune response	ISS	biological_process
GO:0003713	Transcription coactivator activity	TAS	molecular_function
GO:0004672	Protein kinase activity	IDA IMP	molecular_function
GO:0004674	Protein serine/threonine kinase activity	ISS	molecular_function
GO:0004704	NF-kappaB-inducing kinase activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005739	Mitochondrion	IEA	cellular_component
GO:0005829	Cytosol	IDA TAS	cellular_component
GO:0005886	Plasma membrane	IEA	cellular_component
GO:0006464	Cellular protein modification process	TAS	biological_process
GO:0007165	Signal transduction	TAS	biological_process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	biological_process
GO:0010922	Positive regulation of phosphatase activity	IMP	biological_process
GO:0032147	Activation of protein kinase activity	IMP	biological_process
GO:0032403	Protein complex binding	IMP	molecular_function
GO:0032481	Positive regulation of type I interferon production	TAS	biological_process
GO:0032649	Regulation of interferon-gamma production	ISS	biological_process
GO:0033077	T cell differentiation in thymus	ISS	biological_process
GO:0034138	Toll-like receptor 3 signaling pathway	TAS	biological_process
GO:0034142	Toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	biological_process
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0043029	T cell homeostasis	ISS	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0046006	Regulation of activated T cell proliferation	ISS	biological_process
GO:0046777	Protein autophosphorylation	IDA	biological_process
GO:0048535	Lymph node development	ISS	biological_process
GO:0048536	Spleen development	ISS	biological_process
GO:0048538	Thymus development	ISS	biological_process
GO:0051092	Positive regulation of NF-kappaB transcription factor activity	IDA	biological_process
GO:0051260	Protein homooligomerization	IDA	biological_process
GO:0051291	Protein heterooligomerization	IMP	biological_process
GO:0060545	Positive regulation of necroptotic process	IDA IMP	biological_process
GO:0070235	Regulation of activation-induced cell death of T cells	ISS	biological_process
GO:0070266	Necroptotic process	IMP	biological_process
GO:0097190	Apoptotic signaling pathway	TAS	biological_process
GO:1990000	Amyloid fibril formation	IMP	biological_process
GO:2000452	Regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	ISS	biological_process
GO:2001244	Positive regulation of intrinsic apoptotic signaling pathway	IEA	biological_process

Entries Per Page

Displaying Page of

4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.0769455910	0.8074897382	0.5860199363	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0245855692
GSE13712_SHEAR	Up	0.1383231995
GSE13712_STATIC	Up	0.4597737317
GSE19018	Up	0.1243233580
GSE19899_A1	Up	0.0438895708
GSE19899_A2	Up	0.0047942773
PubMed_21979375_A1	Up	0.5815668506
PubMed_21979375_A2	Down	-0.0418284016
GSE35957	Up	0.2440690495
GSE36640	Up	0.0162184590
GSE54402	Down	-0.0189610861
GSE9593	Down	-0.0715097615
GSE43922	Up	0.0135810958
GSE24585	Up	0.1728063739
GSE37065	Up	0.3245459874
GSE28863_A1	Down	-0.1826967929
GSE28863_A2	Up	0.8752346740
GSE28863_A3	Down	-0.4489497802
GSE28863_A4	Up	0.3424504453
GSE48662	Up	0.1820066540

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results