HCSGD entry for SPINK5

1. General information

Official gene symbolSPINK5
Entrez ID11005
Gene full nameserine peptidase inhibitor, Kazal type 5
Other gene symbolsLEKTI LETKI NETS NS VAKTI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004867Serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0005576Extracellular regionIDA NAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0009913Epidermal cell differentiationIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0016525Negative regulation of angiogenesisTASbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030855Epithelial cell differentiationTASbiological_process
GO:0035315Hair cell differentiationTASbiological_process
GO:0042640AnagenTASbiological_process
GO:0045580Regulation of T cell differentiationTASbiological_process
GO:0045861Negative regulation of proteolysisIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050777Negative regulation of immune responseTASbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0097209Epidermal lamellar bodyIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38863896510.71481008320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0580568882
GSE13712_SHEARDown-0.2899939306
GSE13712_STATICUp0.4878814109
GSE19018Up0.1239035438
GSE19899_A1Up0.0814413913
GSE19899_A2Down-0.1463361725
PubMed_21979375_A1Up0.0506169231
PubMed_21979375_A2Down-0.3301016897
GSE35957Up0.3745737539
GSE36640Down-0.0598535856
GSE54402Down-0.0255248237
GSE9593Up0.0593470257
GSE43922Up0.0118351636
GSE24585Up0.0655112684
GSE37065Up0.0625925874
GSE28863_A1Down-0.0741716130
GSE28863_A2Up0.0919852363
GSE28863_A3Up0.1677817128
GSE28863_A4Up0.0562338652
GSE48662Down-0.0560749167

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018086MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.