HCSGD entry for SPINK5
1. General information
| Official gene symbol | SPINK5 |
|---|---|
| Entrez ID | 11005 |
| Gene full name | serine peptidase inhibitor, Kazal type 5 |
| Other gene symbols | LEKTI LETKI NETS NS VAKTI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IDA | molecular_function |
| GO:0005576 | Extracellular region | IDA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0009913 | Epidermal cell differentiation | IDA | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | IDA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | TAS | biological_process |
| GO:0030155 | Regulation of cell adhesion | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030855 | Epithelial cell differentiation | TAS | biological_process |
| GO:0035315 | Hair cell differentiation | TAS | biological_process |
| GO:0042640 | Anagen | TAS | biological_process |
| GO:0045580 | Regulation of T cell differentiation | TAS | biological_process |
| GO:0045861 | Negative regulation of proteolysis | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050777 | Negative regulation of immune response | TAS | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | IDA | biological_process |
| GO:0097209 | Epidermal lamellar body | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3886389651 | 0.7148100832 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0580568882 |
| GSE13712_SHEAR | Down | -0.2899939306 |
| GSE13712_STATIC | Up | 0.4878814109 |
| GSE19018 | Up | 0.1239035438 |
| GSE19899_A1 | Up | 0.0814413913 |
| GSE19899_A2 | Down | -0.1463361725 |
| PubMed_21979375_A1 | Up | 0.0506169231 |
| PubMed_21979375_A2 | Down | -0.3301016897 |
| GSE35957 | Up | 0.3745737539 |
| GSE36640 | Down | -0.0598535856 |
| GSE54402 | Down | -0.0255248237 |
| GSE9593 | Up | 0.0593470257 |
| GSE43922 | Up | 0.0118351636 |
| GSE24585 | Up | 0.0655112684 |
| GSE37065 | Up | 0.0625925874 |
| GSE28863_A1 | Down | -0.0741716130 |
| GSE28863_A2 | Up | 0.0919852363 |
| GSE28863_A3 | Up | 0.1677817128 |
| GSE28863_A4 | Up | 0.0562338652 |
| GSE48662 | Down | -0.0560749167 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018086 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
