HCSGD entry for ADCY2

1. General information

Official gene symbolADCY2
Entrez ID108
Gene full nameadenylate cyclase 2 (brain)
Other gene symbolsAC2 HBAC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0004016Adenylate cyclase activityIEA ISS NASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEA ISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006171CAMP biosynthetic processISSbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008179Adenylate cyclase bindingIEA ISSmolecular_function
GO:0008294Calcium- and calmodulin-responsive adenylate cyclase activityIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030425DendriteIEA ISScellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIEAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEA ISScellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEA ISSmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75076548380.89690194520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0845071436
GSE13712_SHEARDown-0.0276814717
GSE13712_STATICUp0.0224618497
GSE19018Up0.1093431215
GSE19899_A1Up0.0942702020
GSE19899_A2Up0.0554457445
PubMed_21979375_A1Down-0.2392555819
PubMed_21979375_A2Up0.0074604360
GSE35957Up0.1151960801
GSE36640Up0.0664812691
GSE54402Up0.0102493012
GSE9593Down-0.0384227974
GSE43922Up0.0233394672
GSE24585Up0.0528905877
GSE37065Up0.0048540351
GSE28863_A1Down-0.0025070424
GSE28863_A2Up0.0497922211
GSE28863_A3Up0.1542700502
GSE28863_A4Up0.1294611263
GSE48662Up0.0299909462

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ColforsinDB02587 EXPT01467
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDB06843 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17081159Co-immunoprecipitation experiments revealed that Gravin and AKAP79 do not associate with adenylyl cyclase type 2 (AC2) but bind to AC4/6, which interacts with calcium-dependent PKCs alpha/beta both in young and senescent fibroblasts
16516270When the expression of AC II, IV, and VI was blocked by siRNA in senescent fibroblasts, LPA-induced cAMP accumulation was also blocked
16516270These results suggest that the senescence-associated increase of cAMP levels after LPA treatment is associated with reduced Gialpha, increased AC II, IV, and VI proteins, and PKC-dependent stimulation of their activities and provide an explanation for the age-dependent differences in cAMP-related physiological responses
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