HCSGD entry for ADCY2

1. General information

Official gene symbolADCY2
Entrez ID108
Gene full nameadenylate cyclase 2 (brain)
Other gene symbolsAC2 HBAC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0004016Adenylate cyclase activityIEA ISS NASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEA ISScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006171CAMP biosynthetic processISSbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008179Adenylate cyclase bindingIEA ISSmolecular_function
GO:0008294Calcium- and calmodulin-responsive adenylate cyclase activityIEAmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030425DendriteIEA ISScellular_component
GO:0031683G-protein beta/gamma-subunit complex bindingIEAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftIEA ISScellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIEA ISSmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75076548380.89690194520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0845071436
GSE13712_SHEARDown-0.0276814717
GSE13712_STATICUp0.0224618497
GSE19018Up0.1093431215
GSE19899_A1Up0.0942702020
GSE19899_A2Up0.0554457445
PubMed_21979375_A1Down-0.2392555819
PubMed_21979375_A2Up0.0074604360
GSE35957Up0.1151960801
GSE36640Up0.0664812691
GSE54402Up0.0102493012
GSE9593Down-0.0384227974
GSE43922Up0.0233394672
GSE24585Up0.0528905877
GSE37065Up0.0048540351
GSE28863_A1Down-0.0025070424
GSE28863_A2Up0.0497922211
GSE28863_A3Up0.1542700502
GSE28863_A4Up0.1294611263
GSE48662Up0.0299909462

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ColforsinDB02587 EXPT01467
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDB06843 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17081159Co-immunoprecipitation experiments revealed that Gravin and AKAP79 do not associate with adenylyl cyclase type 2 (AC2) but bind to AC4/6, which interacts with calcium-dependent PKCs alpha/beta both in young and senescent fibroblasts
16516270When the expression of AC II, IV, and VI was blocked by siRNA in senescent fibroblasts, LPA-induced cAMP accumulation was also blocked
16516270These results suggest that the senescence-associated increase of cAMP levels after LPA treatment is associated with reduced Gialpha, increased AC II, IV, and VI proteins, and PKC-dependent stimulation of their activities and provide an explanation for the age-dependent differences in cAMP-related physiological responses
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