HCSGD entry for CENPE

1. General information

Official gene symbolCENPE
Entrez ID1062
Gene full namecentromere protein E, 312kDa
Other gene symbolsCENP-E KIF10 PPP1R61
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000089Mitotic metaphaseTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionIDAcellular_component
GO:0000776KinetochoreIDA IEAcellular_component
GO:0000778Condensed nuclear chromosome kinetochoreIEAcellular_component
GO:0000779Condensed chromosome, centromeric regionIDAcellular_component
GO:0000940Condensed chromosome outer kinetochoreIEA TAScellular_component
GO:0003777Microtubule motor activityIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005874MicrotubuleIDA IEAcellular_component
GO:0007018Microtubule-based movementIEA TASbiological_process
GO:0007079Mitotic chromosome movement towards spindle poleTASbiological_process
GO:0007080Mitotic metaphase plate congressionIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008152Metabolic processIMPbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0043515Kinetochore bindingIDA IEAmolecular_function
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0051233Spindle midzoneIEAcellular_component
GO:0051382Kinetochore assemblyNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96061241210.00001090380.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2400432450
GSE13712_SHEARDown-0.5844949237
GSE13712_STATICDown-0.2648129107
GSE19018Up0.1656698976
GSE19899_A1Down-1.8898329028
GSE19899_A2Down-5.2893822043
PubMed_21979375_A1Down-4.5005127784
PubMed_21979375_A2Down-6.0613151959
GSE35957Down-3.3299383702
GSE36640Down-4.0575357999
GSE54402Down-1.5810472628
GSE9593Down-1.4234889348
GSE43922Down-2.4464343717
GSE24585Up0.0205870181
GSE37065Down-0.5434074037
GSE28863_A1Down-0.0537632485
GSE28863_A2Up0.8404986904
GSE28863_A3Down-0.3231308571
GSE28863_A4Up0.0095396476
GSE48662Down-1.7418110916

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GSK-923295DB06097 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024490MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026236MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.