HCSGD entry for CENPE

1. General information

Official gene symbolCENPE
Entrez ID1062
Gene full namecentromere protein E, 312kDa
Other gene symbolsCENP-E KIF10 PPP1R61
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000089Mitotic metaphaseTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000775Chromosome, centromeric regionIDAcellular_component
GO:0000776KinetochoreIDA IEAcellular_component
GO:0000778Condensed nuclear chromosome kinetochoreIEAcellular_component
GO:0000779Condensed chromosome, centromeric regionIDAcellular_component
GO:0000940Condensed chromosome outer kinetochoreIEA TAScellular_component
GO:0003777Microtubule motor activityIEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0005874MicrotubuleIDA IEAcellular_component
GO:0007018Microtubule-based movementIEA TASbiological_process
GO:0007079Mitotic chromosome movement towards spindle poleTASbiological_process
GO:0007080Mitotic metaphase plate congressionIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointIEAbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008152Metabolic processIMPbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0043515Kinetochore bindingIDA IEAmolecular_function
GO:0045860Positive regulation of protein kinase activityIMPbiological_process
GO:0051233Spindle midzoneIEAcellular_component
GO:0051382Kinetochore assemblyNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96061241210.00001090380.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2400432450
GSE13712_SHEARDown-0.5844949237
GSE13712_STATICDown-0.2648129107
GSE19018Up0.1656698976
GSE19899_A1Down-1.8898329028
GSE19899_A2Down-5.2893822043
PubMed_21979375_A1Down-4.5005127784
PubMed_21979375_A2Down-6.0613151959
GSE35957Down-3.3299383702
GSE36640Down-4.0575357999
GSE54402Down-1.5810472628
GSE9593Down-1.4234889348
GSE43922Down-2.4464343717
GSE24585Up0.0205870181
GSE37065Down-0.5434074037
GSE28863_A1Down-0.0537632485
GSE28863_A2Up0.8404986904
GSE28863_A3Down-0.3231308571
GSE28863_A4Up0.0095396476
GSE48662Down-1.7418110916

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GSK-923295DB06097 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024490MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026236MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.