HCSGD entry for NCOA2

1. General information

Official gene symbolNCOA2
Entrez ID10499
Gene full namenuclear receptor coactivator 2
Other gene symbolsGRIP1 KAT13C NCoA-2 SRC2 TIF2 bHLHe75
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIEA NASmolecular_function
GO:0004402Histone acetyltransferase activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEA NASbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIDAmolecular_function
GO:0030375Thyroid hormone receptor coactivator activityIEAmolecular_function
GO:0030521Androgen receptor signaling pathwayRCAbiological_process
GO:0035257Nuclear hormone receptor bindingIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35196681740.07217348500.99999024730.5057716454

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1233755103
GSE13712_SHEARDown-0.5372299106
GSE13712_STATICDown-0.3358292688
GSE19018Up0.1800553093
GSE19899_A1Down-0.4058234077
GSE19899_A2Down-0.9073854840
PubMed_21979375_A1Down-0.7324673593
PubMed_21979375_A2Down-0.4522856895
GSE35957Up0.3598668475
GSE36640Up0.4589909826
GSE54402Down-0.6941805233
GSE9593Up0.1219341919
GSE43922Down-0.9636947808
GSE24585Up0.2624660226
GSE37065Up0.4737844657
GSE28863_A1Up0.5856331346
GSE28863_A2Up0.2039068601
GSE28863_A3Up0.2115537599
GSE28863_A4Up0.1915033647
GSE48662Up0.1340202084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GenisteinDB01645 EXPT01582
MethyltrienoloneDB02998 EXPT02741
17-METHYL-17-ALPHA-DIHYDROEQUILENINDB06871 -
4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDB06898 -
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDEDB07080 -
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07086 -
4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07087 -
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07195 -
(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLDB07678 -
(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLDB07707 -
3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDB07708 -
3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDB07712 -
2-chloro-5-nitro-N-phenylbenzamideDB07863 -
dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateDB07932 -
4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolDB08047 -
4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLDB08048 -
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDB08175 -
DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATEDB08320 -
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINEDB08398 -
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDB08402 -
4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB08595 -
tributylstannanylDB08601 -
RALOXIFENE COREDB08773 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-137MIMAT0000429MIRT004004Luciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI18381414
hsa-miR-193b-3pMIMAT0002819MIRT041215CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-137MIMAT0000429NAhsa-miR-137{Western blot}{overexpression by miRNA precursor transfection}18381414
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.