HCSGD entry for NCOA2

1. General information

Official gene symbolNCOA2
Entrez ID10499
Gene full namenuclear receptor coactivator 2
Other gene symbolsGRIP1 KAT13C NCoA-2 SRC2 TIF2 bHLHe75
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003713Transcription coactivator activityIEA NASmolecular_function
GO:0004402Histone acetyltransferase activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEA NASbiological_process
GO:0016922Ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIDAmolecular_function
GO:0030375Thyroid hormone receptor coactivator activityIEAmolecular_function
GO:0030521Androgen receptor signaling pathwayRCAbiological_process
GO:0035257Nuclear hormone receptor bindingIEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.35196681740.07217348500.99999024730.5057716454

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1233755103
GSE13712_SHEARDown-0.5372299106
GSE13712_STATICDown-0.3358292688
GSE19018Up0.1800553093
GSE19899_A1Down-0.4058234077
GSE19899_A2Down-0.9073854840
PubMed_21979375_A1Down-0.7324673593
PubMed_21979375_A2Down-0.4522856895
GSE35957Up0.3598668475
GSE36640Up0.4589909826
GSE54402Down-0.6941805233
GSE9593Up0.1219341919
GSE43922Down-0.9636947808
GSE24585Up0.2624660226
GSE37065Up0.4737844657
GSE28863_A1Up0.5856331346
GSE28863_A2Up0.2039068601
GSE28863_A3Up0.2115537599
GSE28863_A4Up0.1915033647
GSE48662Up0.1340202084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GenisteinDB01645 EXPT01582
MethyltrienoloneDB02998 EXPT02741
17-METHYL-17-ALPHA-DIHYDROEQUILENINDB06871 -
4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDB06898 -
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDEDB07080 -
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07086 -
4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07087 -
4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB07195 -
(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLDB07678 -
(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLDB07707 -
3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDB07708 -
3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDB07712 -
2-chloro-5-nitro-N-phenylbenzamideDB07863 -
dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateDB07932 -
4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolDB08047 -
4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLDB08048 -
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDB08175 -
DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATEDB08320 -
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINEDB08398 -
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDB08402 -
4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDB08595 -
tributylstannanylDB08601 -
RALOXIFENE COREDB08773 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-137MIMAT0000429MIRT004004Luciferase reporter assay//qRT-PCR//Western blotNon-Functional MTI18381414
hsa-miR-193b-3pMIMAT0002819MIRT041215CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-137MIMAT0000429NAhsa-miR-137{Western blot}{overexpression by miRNA precursor transfection}18381414
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.