HCSGD entry for CREB3

1. General information

Official gene symbolCREB3
Entrez ID10488
Gene full namecAMP responsive element binding protein 3
Other gene symbolsLUMAN LZIP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIDAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0001558Regulation of cell growthIDAbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IMPcellular_component
GO:0005783Endoplasmic reticulumIMPcellular_component
GO:0005789Endoplasmic reticulum membraneIDA IEAcellular_component
GO:0005794Golgi apparatusIMPcellular_component
GO:0005829CytosolIMPcellular_component
GO:0006351Transcription, DNA-templatedIDA IEAbiological_process
GO:0006935ChemotaxisIEAbiological_process
GO:0006986Response to unfolded proteinIEAbiological_process
GO:0006990Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseIDAbiological_process
GO:0008140CAMP response element binding protein bindingIDAmolecular_function
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0016604Nuclear bodyIDAcellular_component
GO:0019043Establishment of viral latencyIDAbiological_process
GO:0019046Release from viral latencyIDA TASbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0031726CCR1 chemokine receptor bindingIDAmolecular_function
GO:0034976Response to endoplasmic reticulum stressIDAbiological_process
GO:0042127Regulation of cell proliferationIMPbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042994Cytoplasmic sequestering of transcription factorIDAbiological_process
GO:0043025Neuronal cell bodyIDAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045786Negative regulation of cell cycleNASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046983Protein dimerization activityTASmolecular_function
GO:0050930Induction of positive chemotaxisIDA IMPbiological_process
GO:0051928Positive regulation of calcium ion transportIMPbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
GO:0090045Positive regulation of deacetylase activityIDAbiological_process
GO:2000326Negative regulation of ligand-dependent nuclear receptor transcription coactivator activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09193344100.20919243950.63769283270.8845227631

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.3444702640
GSE13712_SHEARUp0.2228506726
GSE13712_STATICUp0.1097195295
GSE19018Down-0.3657049733
GSE19899_A1Down-0.7432130657
GSE19899_A2Down-0.2819732098
PubMed_21979375_A1Up0.2085703009
PubMed_21979375_A2Down-0.7910983789
GSE35957Up0.1219950083
GSE36640Up0.6114393257
GSE54402Up0.2588145740
GSE9593Up0.8239682937
GSE43922Down-0.0450658160
GSE24585Up0.4825464384
GSE37065Up0.1173357811
GSE28863_A1Down-0.0951056637
GSE28863_A2Down-0.3359804880
GSE28863_A3Down-0.4773610954
GSE28863_A4Up0.0143265193
GSE48662Up0.0388720730

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019911MicroarrayFunctional MTI (Weak)20215506
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.