HCSGD entry for GNB2L1
1. General information
| Official gene symbol | GNB2L1 |
|---|---|
| Entrez ID | 10399 |
| Gene full name | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 |
| Other gene symbols | Gnb2-rs1 H12.3 HLC-7 PIG21 RACK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001891 | Phagocytic cup | IDA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0005080 | Protein kinase C binding | IDA | molecular_function |
| GO:0005102 | Receptor binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IMP | cellular_component |
| GO:0005829 | Cytosol | IMP | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IDA | biological_process |
| GO:0006919 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007369 | Gastrulation | IEA | biological_process |
| GO:0008200 | Ion channel inhibitor activity | IEA ISS | molecular_function |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | IMP | molecular_function |
| GO:0015935 | Small ribosomal subunit | IEA ISS | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0017148 | Negative regulation of translation | IEA ISS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0030178 | Negative regulation of Wnt signaling pathway | ISS | biological_process |
| GO:0030292 | Protein tyrosine kinase inhibitor activity | IDA | molecular_function |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0030425 | Dendrite | IEA ISS | cellular_component |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0030822 | Positive regulation of cAMP catabolic process | IMP | biological_process |
| GO:0030971 | Receptor tyrosine kinase binding | IDA | molecular_function |
| GO:0032436 | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0032464 | Positive regulation of protein homooligomerization | IDA IMP | biological_process |
| GO:0032880 | Regulation of protein localization | ISS | biological_process |
| GO:0032947 | Protein complex scaffold | TAS | molecular_function |
| GO:0042169 | SH2 domain binding | IDA | molecular_function |
| GO:0042326 | Negative regulation of phosphorylation | IDA | biological_process |
| GO:0043025 | Neuronal cell body | IEA ISS | cellular_component |
| GO:0043065 | Positive regulation of apoptotic process | IDA IMP | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0043204 | Perikaryon | IEA | cellular_component |
| GO:0043547 | Positive regulation of GTPase activity | IDA | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048511 | Rhythmic process | IEA | biological_process |
| GO:0050765 | Negative regulation of phagocytosis | IMP | biological_process |
| GO:0051302 | Regulation of cell division | ISS | biological_process |
| GO:0051343 | Positive regulation of cyclic-nucleotide phosphodiesterase activity | IMP | biological_process |
| GO:0051726 | Regulation of cell cycle | IDA | biological_process |
| GO:0051898 | Negative regulation of protein kinase B signaling | IMP | biological_process |
| GO:0051901 | Positive regulation of mitochondrial depolarization | IMP | biological_process |
| GO:0061099 | Negative regulation of protein tyrosine kinase activity | IDA | biological_process |
| GO:0090003 | Regulation of establishment of protein localization to plasma membrane | IEA | biological_process |
| GO:2000114 | Regulation of establishment of cell polarity | ISS | biological_process |
| GO:2000543 | Positive regulation of gastrulation | ISS | biological_process |
| GO:2001244 | Positive regulation of intrinsic apoptotic signaling pathway | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9945078227 | 0.1203423160 | 0.9999902473 | 0.6662412829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0167488936 |
| GSE28863_A2 | Down | -0.1233079140 |
| GSE28863_A3 | Down | -0.0565139737 |
| GSE28863_A4 | Down | -0.2834289752 |
| GSE48662 | Down | -0.2920369316 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022376 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035920 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036490 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037295 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037457 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038427 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-2-3p | MIMAT0004550 | MIRT038703 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042687 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042818 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044905 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT045841 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046286 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047084 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT048375 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050672 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20099848 | Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis |
| 20099848 | Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in vitro cell senescence |
| 20099848 | Furthermore, knockdown of Rack1 by siRNA could promote NIH/3T3 cell senescence |
| 20099848 | Taken together, our results suggest that Rack1, EF-Tu and Rhodanese are aging-related proteins in human colonic epithelium, and injury of mitochondrial function and decline of antioxidant capability are important reasons for the aging of human colonic epithelium |
Entries Per Page
Displaying Page of
