HCSGD entry for GNB2L1

1. General information

Official gene symbolGNB2L1
Entrez ID10399
Gene full nameguanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Other gene symbolsGnb2-rs1 H12.3 HLC-7 PIG21 RACK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001891Phagocytic cupIDAcellular_component
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0005080Protein kinase C bindingIDAmolecular_function
GO:0005102Receptor bindingNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIMPcellular_component
GO:0005829CytosolIMPcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007369GastrulationIEAbiological_process
GO:0008200Ion channel inhibitor activityIEA ISSmolecular_function
GO:0008656Cysteine-type endopeptidase activator activity involved in apoptotic processIMPmolecular_function
GO:0015935Small ribosomal subunitIEA ISScellular_component
GO:0016032Viral processIEAbiological_process
GO:0017148Negative regulation of translationIEA ISSbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030178Negative regulation of Wnt signaling pathwayISSbiological_process
GO:0030292Protein tyrosine kinase inhibitor activityIDAmolecular_function
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030425DendriteIEA ISScellular_component
GO:0030496MidbodyIDAcellular_component
GO:0030822Positive regulation of cAMP catabolic processIMPbiological_process
GO:0030971Receptor tyrosine kinase bindingIDAmolecular_function
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0032464Positive regulation of protein homooligomerizationIDA IMPbiological_process
GO:0032880Regulation of protein localizationISSbiological_process
GO:0032947Protein complex scaffoldTASmolecular_function
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042326Negative regulation of phosphorylationIDAbiological_process
GO:0043025Neuronal cell bodyIEA ISScellular_component
GO:0043065Positive regulation of apoptotic processIDA IMPbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0043547Positive regulation of GTPase activityIDAbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048511Rhythmic processIEAbiological_process
GO:0050765Negative regulation of phagocytosisIMPbiological_process
GO:0051302Regulation of cell divisionISSbiological_process
GO:0051343Positive regulation of cyclic-nucleotide phosphodiesterase activityIMPbiological_process
GO:0051726Regulation of cell cycleIDAbiological_process
GO:0051898Negative regulation of protein kinase B signalingIMPbiological_process
GO:0051901Positive regulation of mitochondrial depolarizationIMPbiological_process
GO:0061099Negative regulation of protein tyrosine kinase activityIDAbiological_process
GO:0090003Regulation of establishment of protein localization to plasma membraneIEAbiological_process
GO:2000114Regulation of establishment of cell polarityISSbiological_process
GO:2000543Positive regulation of gastrulationISSbiological_process
GO:2001244Positive regulation of intrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99450782270.12034231600.99999024730.6662412829

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0167488936
GSE28863_A2Down-0.1233079140
GSE28863_A3Down-0.0565139737
GSE28863_A4Down-0.2834289752
GSE48662Down-0.2920369316

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022376Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-1180-3pMIMAT0005825MIRT035920CLASHFunctional MTI (Weak)23622248
hsa-miR-1226-3pMIMAT0005577MIRT036490CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037295CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037457CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038427CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-2-3pMIMAT0004550MIRT038703CLASHFunctional MTI (Weak)23622248
hsa-miR-196b-5pMIMAT0001080MIRT042687CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042818CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043051CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT044905CLASHFunctional MTI (Weak)23622248
hsa-miR-132-3pMIMAT0000426MIRT045841CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046286CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047084CLASHFunctional MTI (Weak)23622248
hsa-miR-29b-3pMIMAT0000100MIRT048375CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050672CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20099848Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis
20099848Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in vitro cell senescence
20099848Furthermore, knockdown of Rack1 by siRNA could promote NIH/3T3 cell senescence
20099848Taken together, our results suggest that Rack1, EF-Tu and Rhodanese are aging-related proteins in human colonic epithelium, and injury of mitochondrial function and decline of antioxidant capability are important reasons for the aging of human colonic epithelium
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