HCSGD entry for TOPORS

1. General information

Official gene symbolTOPORS
Entrez ID10210
Gene full nametopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Other gene symbolsLUN P53BP3 RP31 TP53BPL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000922Spindle poleIDAcellular_component
GO:0000930Gamma-tubulin complexIDAcellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0003823Antigen bindingIPImolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005814CentrioleIDAcellular_component
GO:0005868Cytoplasmic dynein complexTAScellular_component
GO:0006351Transcription, DNA-templatedNASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIDAbiological_process
GO:0010842Retina layer formationISSbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0016607Nuclear speckIDAcellular_component
GO:0016925Protein sumoylationIDA IMPbiological_process
GO:0019789SUMO ligase activityIDA IMPmolecular_function
GO:0030496MidbodyTAScellular_component
GO:0032391Photoreceptor connecting ciliumIDAcellular_component
GO:0034504Protein localization to nucleusIMPbiological_process
GO:0035845Photoreceptor cell outer segment organizationISSbiological_process
GO:0036064Ciliary basal bodyIDAcellular_component
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEAbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0044547DNA topoisomerase bindingIPImolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046548Retinal rod cell developmentISSbiological_process
GO:0046549Retinal cone cell developmentISSbiological_process
GO:0051443Positive regulation of ubiquitin-protein ligase activityIDAbiological_process
GO:0051457Maintenance of protein location in nucleusIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09944715630.37763767710.65833717301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0321912689
GSE13712_SHEARUp0.2951353635
GSE13712_STATICUp0.2441724889
GSE19018Up0.2918157974
GSE19899_A1Up0.7714290134
GSE19899_A2Down-0.0763463911
PubMed_21979375_A1Up0.9228677399
PubMed_21979375_A2Up0.9470495797
GSE35957Up0.0646334588
GSE36640Up0.0318611400
GSE54402Up0.2024110207
GSE9593Down-0.4388242617
GSE43922Up0.2143405417
GSE24585Down-0.0169545796
GSE37065Up0.1909286220
GSE28863_A1Down-0.3495117679
GSE28863_A2Down-0.4706819436
GSE28863_A3Down-0.5757619434
GSE28863_A4Up0.1585187481
GSE48662Down-0.5171915218

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT005324Luciferase reporter assay//qRT-PCRFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT005324MicroarrayFunctional MTI (Weak)18591254
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.