HCSGD entry for TOPORS

1. General information

Official gene symbolTOPORS
Entrez ID10210
Gene full nametopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Other gene symbolsLUN P53BP3 RP31 TP53BPL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000922Spindle poleIDAcellular_component
GO:0000930Gamma-tubulin complexIDAcellular_component
GO:0003677DNA bindingIDAmolecular_function
GO:0003823Antigen bindingIPImolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005814CentrioleIDAcellular_component
GO:0005868Cytoplasmic dynein complexTAScellular_component
GO:0006351Transcription, DNA-templatedNASbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIDAbiological_process
GO:0010842Retina layer formationISSbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0016607Nuclear speckIDAcellular_component
GO:0016925Protein sumoylationIDA IMPbiological_process
GO:0019789SUMO ligase activityIDA IMPmolecular_function
GO:0030496MidbodyTAScellular_component
GO:0032391Photoreceptor connecting ciliumIDAcellular_component
GO:0034504Protein localization to nucleusIMPbiological_process
GO:0035845Photoreceptor cell outer segment organizationISSbiological_process
GO:0036064Ciliary basal bodyIDAcellular_component
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIEAbiological_process
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIMPbiological_process
GO:0044547DNA topoisomerase bindingIPImolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046548Retinal rod cell developmentISSbiological_process
GO:0046549Retinal cone cell developmentISSbiological_process
GO:0051443Positive regulation of ubiquitin-protein ligase activityIDAbiological_process
GO:0051457Maintenance of protein location in nucleusIDAbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09944715630.37763767710.65833717301.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0321912689
GSE13712_SHEARUp0.2951353635
GSE13712_STATICUp0.2441724889
GSE19018Up0.2918157974
GSE19899_A1Up0.7714290134
GSE19899_A2Down-0.0763463911
PubMed_21979375_A1Up0.9228677399
PubMed_21979375_A2Up0.9470495797
GSE35957Up0.0646334588
GSE36640Up0.0318611400
GSE54402Up0.2024110207
GSE9593Down-0.4388242617
GSE43922Up0.2143405417
GSE24585Down-0.0169545796
GSE37065Up0.1909286220
GSE28863_A1Down-0.3495117679
GSE28863_A2Down-0.4706819436
GSE28863_A3Down-0.5757619434
GSE28863_A4Up0.1585187481
GSE48662Down-0.5171915218

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT005324Luciferase reporter assay//qRT-PCRFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT005324MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.