HCSGD entry for TNK2

1. General information

Official gene symbolTNK2
Entrez ID10188
Gene full nametyrosine kinase, non-receptor, 2
Other gene symbolsACK ACK-1 ACK1 p21cdc42Hs
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005095GTPase inhibitor activityTASmolecular_function
GO:0005154Epidermal growth factor receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeISScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005905Coated pitIDAcellular_component
GO:0005912Adherens junctionIEAcellular_component
GO:0006897EndocytosisIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDA TASbiological_process
GO:0030136Clathrin-coated vesicleIDAcellular_component
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043086Negative regulation of catalytic activityTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050699WW domain bindingISSmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0070436Grb2-EGFR complexIDAcellular_component
GO:2000369Regulation of clathrin-mediated endocytosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86501051250.62726160100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1001951619
GSE13712_SHEARDown-0.2152539682
GSE13712_STATICDown-0.4044392087
GSE19018Up0.0230505685
GSE19899_A1Down-0.0763022511
GSE19899_A2Up0.2064008946
PubMed_21979375_A1Down-0.0350821755
PubMed_21979375_A2Up0.0268727152
GSE35957Up0.0082458643
GSE36640Up0.1236511741
GSE54402Up0.0027777535
GSE9593Up0.0367058002
GSE43922Up0.0347113718
GSE24585Down-0.0403291013
GSE37065Down-0.0058869345
GSE28863_A1Down-0.1327997525
GSE28863_A2Up0.0655231571
GSE28863_A3Up0.2159549630
GSE28863_A4Down-0.0094949641
GSE48662Up0.0739797040

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
DebromohymenialdisineDB04367 EXPT01124

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041931CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-7-5pMIMAT0000252NAhsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}21156648
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.