HCSGD entry for TNK2

1. General information

Official gene symbolTNK2
Entrez ID10188
Gene full nametyrosine kinase, non-receptor, 2
Other gene symbolsACK ACK-1 ACK1 p21cdc42Hs
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityIDA IEAmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005095GTPase inhibitor activityTASmolecular_function
GO:0005154Epidermal growth factor receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeISScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005905Coated pitIDAcellular_component
GO:0005912Adherens junctionIEAcellular_component
GO:0006897EndocytosisIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDA TASbiological_process
GO:0030136Clathrin-coated vesicleIDAcellular_component
GO:0030424AxonIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043086Negative regulation of catalytic activityTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050699WW domain bindingISSmolecular_function
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0070436Grb2-EGFR complexIDAcellular_component
GO:2000369Regulation of clathrin-mediated endocytosisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86501051250.62726160100.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1001951619
GSE13712_SHEARDown-0.2152539682
GSE13712_STATICDown-0.4044392087
GSE19018Up0.0230505685
GSE19899_A1Down-0.0763022511
GSE19899_A2Up0.2064008946
PubMed_21979375_A1Down-0.0350821755
PubMed_21979375_A2Up0.0268727152
GSE35957Up0.0082458643
GSE36640Up0.1236511741
GSE54402Up0.0027777535
GSE9593Up0.0367058002
GSE43922Up0.0347113718
GSE24585Down-0.0403291013
GSE37065Down-0.0058869345
GSE28863_A1Down-0.1327997525
GSE28863_A2Up0.0655231571
GSE28863_A3Up0.2159549630
GSE28863_A4Down-0.0094949641
GSE48662Up0.0739797040

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
DebromohymenialdisineDB04367 EXPT01124

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041931CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-7-5pMIMAT0000252NAhsa-miR-7{Western blot}{overexpression by miRNA precursor transfection}21156648
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.