HCSGD entry for PARP3

1. General information

Official gene symbolPARP3
Entrez ID10039
Gene full namepoly (ADP-ribose) polymerase family, member 3
Other gene symbolsADPRT3 ADPRTL2 ADPRTL3 ARTD3 IRT1 PADPRT-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000723Telomere maintenanceIMPbiological_process
GO:0003824Catalytic activityTASmolecular_function
GO:0003950NAD+ ADP-ribosyltransferase activityIDA IEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005814CentrioleIEAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIDA IMPbiological_process
GO:0006471Protein ADP-ribosylationIDA IEAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0051106Positive regulation of DNA ligationIGIbiological_process
GO:0060236Regulation of mitotic spindle organizationIMPbiological_process
GO:1990166Protein localization to site of double-strand breakIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48124110790.16727701460.99999024730.7904664811

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0580993302
GSE13712_SHEARUp0.0261056494
GSE13712_STATICDown-0.0484095405
GSE19018Up0.1190985894
GSE19899_A1Down-0.0500875838
GSE19899_A2Down-0.4644508658
PubMed_21979375_A1Down-0.4761324093
PubMed_21979375_A2Down-0.9301972988
GSE35957Down-0.4476276087
GSE36640Up0.1370171819
GSE54402Up0.0779128042
GSE9593Up0.6210358584
GSE43922Down-1.1155632205
GSE24585Up0.3704085232
GSE37065Up0.0293358397
GSE28863_A1Up0.1100721885
GSE28863_A2Up0.1056224596
GSE28863_A3Up0.2030399310
GSE28863_A4Down-0.0877725227
GSE48662Down-0.0186042717

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-oneDB07677 -
4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-oneDB08058 -
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDB08348 -
OlaparibDB09074 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.