HCSGD entry for PARP3

1. General information

Official gene symbolPARP3
Entrez ID10039
Gene full namepoly (ADP-ribose) polymerase family, member 3
Other gene symbolsADPRT3 ADPRTL2 ADPRTL3 ARTD3 IRT1 PADPRT-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000723Telomere maintenanceIMPbiological_process
GO:0003824Catalytic activityTASmolecular_function
GO:0003950NAD+ ADP-ribosyltransferase activityIDA IEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005814CentrioleIEAcellular_component
GO:0006281DNA repairTASbiological_process
GO:0006302Double-strand break repairIDA IMPbiological_process
GO:0006471Protein ADP-ribosylationIDA IEAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0051106Positive regulation of DNA ligationIGIbiological_process
GO:0060236Regulation of mitotic spindle organizationIMPbiological_process
GO:1990166Protein localization to site of double-strand breakIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48124110790.16727701460.99999024730.7904664811

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0580993302
GSE13712_SHEARUp0.0261056494
GSE13712_STATICDown-0.0484095405
GSE19018Up0.1190985894
GSE19899_A1Down-0.0500875838
GSE19899_A2Down-0.4644508658
PubMed_21979375_A1Down-0.4761324093
PubMed_21979375_A2Down-0.9301972988
GSE35957Down-0.4476276087
GSE36640Up0.1370171819
GSE54402Up0.0779128042
GSE9593Up0.6210358584
GSE43922Down-1.1155632205
GSE24585Up0.3704085232
GSE37065Up0.0293358397
GSE28863_A1Up0.1100721885
GSE28863_A2Up0.1056224596
GSE28863_A3Up0.2030399310
GSE28863_A4Down-0.0877725227
GSE48662Down-0.0186042717

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-oneDB07677 -
4-[3-(1,4-diazepan-1-ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-oneDB08058 -
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDB08348 -
OlaparibDB09074 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.