HCSGD entry for KCNE2

1. General information

Official gene symbolKCNE2
Entrez ID9992
Gene full namepotassium voltage-gated channel, Isk-related family, member 2
Other gene symbolsATFB4 LQT5 LQT6 MIRP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005242Inward rectifier potassium channel activityIDAmolecular_function
GO:0005251Delayed rectifier potassium channel activityIDAmolecular_function
GO:0005764LysosomeIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007568AgingIEAbiological_process
GO:0008076Voltage-gated potassium channel complexIDAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010107Potassium ion importIMPbiological_process
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0034613Cellular protein localizationIEAbiological_process
GO:0035690Cellular response to drugIDAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043586Tongue developmentIEAbiological_process
GO:0044325Ion channel bindingIDAmolecular_function
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0071435Potassium ion exportIDAbiological_process
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086009Membrane repolarizationIDAbiological_process
GO:0086011Membrane repolarization during action potentialIMPbiological_process
GO:0086013Membrane repolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:1901379Regulation of potassium ion transmembrane transportIDAbiological_process
GO:1901800Positive regulation of proteasomal protein catabolic processIDAbiological_process
GO:1901979Regulation of inward rectifier potassium channel activityIDAbiological_process
GO:1902159Regulation of cyclic nucleotide-gated ion channel activityIEAbiological_process
GO:1902259Regulation of delayed rectifier potassium channel activityIDAbiological_process
GO:1902282Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationIMPmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.82062232440.55464326960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0132759289
GSE13712_SHEARDown-0.1743296599
GSE13712_STATICUp0.0440824965
GSE19018Up0.0572863918
GSE19899_A1Up0.1251602572
GSE19899_A2Up0.1268653864
PubMed_21979375_A1Down-0.1083018089
PubMed_21979375_A2Down-0.6776511807
GSE35957Up0.1393979885
GSE36640Up0.1453934170
GSE54402Down-0.0890608151
GSE9593Up0.1403433325
GSE43922Down-0.0027426632
GSE24585Down-0.0431894847
GSE37065Up0.1209035542
GSE28863_A1Down-0.1421408921
GSE28863_A2Down-0.1655845393
GSE28863_A3Up0.1523658144
GSE28863_A4Up0.0080765186
GSE48662Down-0.0375091772

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.