HCSGD entry for GGPS1

1. General information

Official gene symbolGGPS1
Entrez ID9453
Gene full namegeranylgeranyl diphosphate synthase 1
Other gene symbolsGGPPS GGPPS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004161Dimethylallyltranstransferase activityIEAmolecular_function
GO:0004311Farnesyltranstransferase activityIDAmolecular_function
GO:0004337Geranyltranstransferase activityIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006695Cholesterol biosynthetic processTASbiological_process
GO:0006720Isoprenoid metabolic processIDAbiological_process
GO:0008299Isoprenoid biosynthetic processIEAbiological_process
GO:0033384Geranyl diphosphate biosynthetic processIEAbiological_process
GO:0033386Geranylgeranyl diphosphate biosynthetic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045337Farnesyl diphosphate biosynthetic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15555907070.80244772990.78363067941.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3001091649
GSE13712_SHEARUp0.0309326271
GSE13712_STATICUp0.0610024094
GSE19018Up0.2945921315
GSE19899_A1Up0.1450794368
GSE19899_A2Up0.5637563114
PubMed_21979375_A1Down-0.7006853350
PubMed_21979375_A2Down-0.0215704573
GSE35957Down-0.1710623902
GSE36640Up0.8730628345
GSE54402Up0.0726532645
GSE9593Up0.2741522072
GSE43922Up0.0384587594
GSE24585Up0.2594663093
GSE37065Up0.0855646513
GSE28863_A1Down-0.0904045068
GSE28863_A2Up0.1003163446
GSE28863_A3Down-0.2336221214
GSE28863_A4Down-0.3010118165
GSE48662Down-0.0871352790

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Zoledronic acidDB00399 APRD01294 | DB06286
Geranyl DiphosphateDB02552 EXPT01640
FARNESYL THIOPYROPHOSPHATEDB04695 -
ISOPENTENYL PYROPHOSPHATEDB04714 -
(1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)DB06830 -
(1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)DB06931 -
(2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUMDB07221 -
[2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACIDDB07410 -
FARNESYL DIPHOSPHATEDB07780 -
GERANYLGERANYL DIPHOSPHATEDB07841 -
(1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)DB07873 -
(6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)DB08529 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-769-5pMIMAT0003886MIRT039170CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045310CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052321CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052559CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.