HCSGD entry for CCKBR

1. General information

Official gene symbolCCKBR
Entrez ID887
Gene full namecholecystokinin B receptor
Other gene symbolsCCK-B CCK2R GASR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001696Gastric acid secretionIEAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004951Cholecystokinin receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0007166Cell surface receptor signaling pathwayNASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007586DigestionTASbiological_process
GO:0007600Sensory perceptionTASbiological_process
GO:0007631Feeding behaviorTASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0015054Gastrin receptor activityIDA IEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0031741Type B gastrin/cholecystokinin receptor bindingIDAmolecular_function
GO:0038188Cholecystokinin signaling pathwayTASbiological_process
GO:0042325Regulation of phosphorylationTASbiological_process
GO:0043551Regulation of phosphatidylinositol 3-kinase activityTASbiological_process
GO:00469351-phosphatidylinositol-3-kinase regulator activityTASmolecular_function
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048732Gland developmentIEAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62736918810.88702595650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0310873747
GSE13712_SHEARDown-0.0476502259
GSE13712_STATICUp0.0556648386
GSE19018Up0.0144296701
GSE19899_A1Up0.1190595176
GSE19899_A2Down-0.0272156271
PubMed_21979375_A1Up0.0135247222
PubMed_21979375_A2Down-0.0161454086
GSE35957Up0.0298791009
GSE36640Up0.1455624412
GSE54402Down-0.0751687337
GSE9593Up0.1425485406
GSE43922Up0.0625407977
GSE24585Down-0.0960549689
GSE37065Down-0.1437324513
GSE28863_A1Up0.0456183507
GSE28863_A2Down-0.0908759152
GSE28863_A3Up0.2079495130
GSE28863_A4Up0.1415105779
GSE48662Up0.0959716666

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PentagastrinDB00183 APRD01172

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT005759Luciferase reporter assayFunctional MTI21205300
hsa-miR-148b-3pMIMAT0000759MIRT005759In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22020560
hsa-miR-148a-3pMIMAT0000243MIRT005898Luciferase reporter assay//MicroarrayFunctional MTI21168126
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-148b-3pMIMAT0000759NAhsa-miR-148b{Western blot}{overexpression by miRNA mimics tranfection}21205300
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.