HCSGD entry for NPHS2

1. General information

Official gene symbolNPHS2
Entrez ID7827
Gene full namenephrosis 2, idiopathic, steroid-resistant (podocin)
Other gene symbolsPDCN SRN1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007588ExcretionIEAbiological_process
GO:0031235Intrinsic component of the cytoplasmic side of the plasma membraneIDAcellular_component
GO:0031532Actin cytoskeleton reorganizationIDAbiological_process
GO:0036057Slit diaphragmIDAcellular_component
GO:0043234Protein complexIDAcellular_component
GO:0045121Membrane raftIDAcellular_component
GO:0072249Metanephric glomerular visceral epithelial cell developmentIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69229653890.67912050830.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0130686383
GSE13712_SHEARDown-0.1585822311
GSE13712_STATICDown-0.2761387426
GSE19018Up0.1834690968
GSE19899_A1Up0.0076148483
GSE19899_A2Up0.0138144829
PubMed_21979375_A1Up0.0982060019
PubMed_21979375_A2Up0.1859012259
GSE35957Up0.1641818318
GSE36640Down-0.0466478268
GSE54402Up0.0732702025
GSE9593Down-0.1260112950
GSE43922Up0.0239821315
GSE24585Down-0.0915358790
GSE37065Down-0.1011736893
GSE28863_A1Down-0.0548592609
GSE28863_A2Down-0.0151108994
GSE28863_A3Up0.0832247868
GSE28863_A4Up0.1103401179
GSE48662Up0.2615995469

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018421MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.