HCSGD entry for CACNA1S

1. General information

Official gene symbolCACNA1S
Entrez ID779
Gene full namecalcium channel, voltage-dependent, L type, alpha 1S subunit
Other gene symbolsCACNL1A3 CCHL1A3 Cav1.1 HOKPP HOKPP1 MHS5 TTPP1 hypoPP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0002074Extraocular skeletal muscle developmentIEAbiological_process
GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006816Calcium ion transportIDAbiological_process
GO:0006936Muscle contractionIMPbiological_process
GO:0006941Striated muscle contractionIEAbiological_process
GO:0007029Endoplasmic reticulum organizationIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007520Myoblast fusionIEAbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0008331High voltage-gated calcium channel activityIDAmolecular_function
GO:0016529Sarcoplasmic reticulumIEAcellular_component
GO:0030315T-tubuleIDAcellular_component
GO:0031674I bandIDAcellular_component
GO:0043501Skeletal muscle adaptationIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048741Skeletal muscle fiber developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42743471750.95061404200.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2374638242
GSE13712_SHEARDown-0.1109546922
GSE13712_STATICUp0.0299225051
GSE19018Up0.0234055042
GSE19899_A1Up0.1002846164
GSE19899_A2Up0.1666729246
PubMed_21979375_A1Up0.0342717214
PubMed_21979375_A2Up0.0471650355
GSE35957Up0.4137441689
GSE36640Up0.0712507951
GSE54402Up0.1685769368
GSE9593Down-0.0298610738
GSE43922Up0.0168543487
GSE24585Up0.0410517143
GSE37065Down-0.0282009568
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.0432226465

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsradipineDB00270 APRD00298
NisoldipineDB00401 APRD00635
CinnarizineDB00568 APRD00332
Magnesium SulfateDB00653 APRD01080
VerapamilDB00661 APRD00335
NitrendipineDB01054 APRD00421
NifedipineDB01115 APRD00590
MibefradilDB01388 -
DronedaroneDB04855 -
ClevidipineDB04920 -
NilvadipineDB06712 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029696MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.