HCSGD entry for TRH

1. General information

Official gene symbolTRH
Entrez ID7200
Gene full namethyrotropin-releasing hormone
Other gene symbolsTRF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001692Histamine metabolic processIEAbiological_process
GO:0005184Neuropeptide hormone activityIEAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008437Thyrotropin-releasing hormone activityIEAmolecular_function
GO:0009409Response to coldIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0009755Hormone-mediated signaling pathwayIEAbiological_process
GO:0014050Negative regulation of glutamate secretionIEAbiological_process
GO:0014054Positive regulation of gamma-aminobutyric acid secretionIEAbiological_process
GO:0030141Secretory granuleIEAcellular_component
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:2000252Negative regulation of feeding behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23113862320.75178890240.91467525561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0173771954
GSE13712_SHEARDown-0.0306650588
GSE13712_STATICUp0.0264087163
GSE19018Up0.1811927339
GSE19899_A1Up0.1726199903
GSE19899_A2Up0.0249725781
PubMed_21979375_A1Up0.1735329967
PubMed_21979375_A2Down-0.1672695257
GSE35957Up0.4507256413
GSE36640Up0.0529917311
GSE54402Down-0.2321062659
GSE9593Up0.3233157938
GSE43922Up0.0070334992
GSE24585Up0.0956874379
GSE37065Up0.0101446376
GSE28863_A1Down-0.1137675182
GSE28863_A2Down-0.0352562632
GSE28863_A3Up0.1498595068
GSE28863_A4Up0.0071757026
GSE48662Up1.2795686391

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9818729Coincubation of thymulin with TRH revealed a synergistic release of PRL and TSH in AP cells from all age groups
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