HCSGD entry for MAVS

1. General information

Official gene symbolMAVS
Entrez ID57506
Gene full namemitochondrial antiviral signaling protein
Other gene symbolsCARDIF IPS-1 IPS1 VISA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0002218Activation of innate immune responseIMPbiological_process
GO:0002230Positive regulation of defense response to virus by hostIDA IMPbiological_process
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005741Mitochondrial outer membraneIDA TAScellular_component
GO:0005778Peroxisomal membraneIDAcellular_component
GO:0007165Signal transductionIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031966Mitochondrial membraneIDAcellular_component
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032727Positive regulation of interferon-alpha productionIDA IMPbiological_process
GO:0032728Positive regulation of interferon-beta productionIDA IMPbiological_process
GO:0032757Positive regulation of interleukin-8 productionIDAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDAbiological_process
GO:0033160Positive regulation of protein import into nucleus, translocationIDAbiological_process
GO:0039529RIG-I signaling pathwayIEAbiological_process
GO:0042742Defense response to bacteriumIMPbiological_process
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045087Innate immune responseIMP TASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0050700CARD domain bindingIPImolecular_function
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051607Defense response to virusIDAbiological_process
GO:0060340Positive regulation of type I interferon-mediated signaling pathwayIDAbiological_process
GO:0071360Cellular response to exogenous dsRNAIMPbiological_process
GO:0071651Positive regulation of chemokine (C-C motif) ligand 5 productionIDAbiological_process
GO:0071660Positive regulation of IP-10 productionIDAbiological_process
GO:1900063Regulation of peroxisome organizationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23446989480.75714799210.91763380371.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0326868154
GSE13712_SHEARUp0.2950335767
GSE13712_STATICDown-0.0284205231
GSE19018Down-0.1518495781
GSE19899_A1Down-0.4708496571
GSE19899_A2Up0.2124097669
PubMed_21979375_A1Up0.2661116376
PubMed_21979375_A2Up0.3964768441
GSE35957Up0.0519622907
GSE36640Down-0.0129261983
GSE54402Up0.1333096738
GSE9593Up0.3340886884
GSE43922Up0.0552651429
GSE24585Up0.3163950775
GSE37065Down-0.3892457400
GSE28863_A1Up0.4253880132
GSE28863_A2Up0.0961289350
GSE28863_A3Down-0.0971411900
GSE28863_A4Down-0.0959666008
GSE48662Up0.0724467249

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020812ProteomicsFunctional MTI (Weak)18668040
hsa-miR-186-5pMIMAT0000456MIRT045289CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049317CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.