HCSGD entry for KLK6

1. General information

Official gene symbolKLK6
Entrez ID5653
Gene full namekallikrein-related peptidase 6
Other gene symbolsBssp Klk7 PRSS18 PRSS9 SP59 hK6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIDA IEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0007417Central nervous system developmentNASbiological_process
GO:0009611Response to woundingNASbiological_process
GO:0010975Regulation of neuron projection developmentIEAbiological_process
GO:0016540Protein autoprocessingNASbiological_process
GO:0030574Collagen catabolic processNASbiological_process
GO:0042246Tissue regenerationNASbiological_process
GO:0042445Hormone metabolic processNASbiological_process
GO:0042552MyelinationNASbiological_process
GO:0042982Amyloid precursor protein metabolic processNASbiological_process
GO:0045595Regulation of cell differentiationNASbiological_process
GO:0045745Positive regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66504171190.62612787510.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0173914649
GSE13712_SHEARDown-0.3655034582
GSE13712_STATICDown-0.0923497596
GSE19018Up0.0666668856
GSE19899_A1Up0.1718519048
GSE19899_A2Up0.2195444330
PubMed_21979375_A1Up0.2313290132
PubMed_21979375_A2Down-0.0765793628
GSE35957Down-0.0910999650
GSE36640Down-0.0028014827
GSE54402Down-0.0089726090
GSE9593Up0.0029621243
GSE43922Up0.1345676450
GSE24585Down-0.3806779825
GSE37065Down-0.2286331476
GSE28863_A1Up0.0559121671
GSE28863_A2Down-0.0402806903
GSE28863_A3Up0.3353000661
GSE28863_A4Up0.0482795140
GSE48662Up0.0326740504

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

BenzamidineDB03127 EXPT00669

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7f-5pMIMAT0000067MIRT004678ELISA//Luciferase reporter assay//qRT-PCRFunctional MTI18627289
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.