HCSGD entry for ANAPC5


1. General information

Official gene symbolANAPC5
Entrez ID51433
Gene full nameanaphase promoting complex subunit 5
Other gene symbolsAPC5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000090Mitotic anaphaseTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004842Ubiquitin-protein ligase activityTASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.49398550970.49844236160.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3243606173
GSE13712_SHEARUp0.0383108049
GSE13712_STATICDown-0.0408417298
GSE19018Up0.0273977426
GSE19899_A1Up0.0275276437
GSE19899_A2Down-0.1907629682
PubMed_21979375_A1Down-0.2247286332
PubMed_21979375_A2Down-0.3600438788
GSE35957Down-0.2542367946
GSE36640Up0.1033760415
GSE54402Up0.0473409189
GSE9593Down-0.0470611332
GSE43922Up0.0181954309
GSE24585Up0.0885178272
GSE37065Down-0.0939832948
GSE28863_A1Up0.7987344402
GSE28863_A2Up0.3641290281
GSE28863_A3Down-0.0541211406
GSE28863_A4Down-0.0885847356
GSE48662Down-0.4639194705

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022451Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1227-3pMIMAT0005580MIRT036395CLASHFunctional MTI (Weak)23622248
hsa-miR-26b-3pMIMAT0004500MIRT038955CLASHFunctional MTI (Weak)23622248
hsa-miR-34a-5pMIMAT0000255MIRT047361CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048874CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049952CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.