HCSGD entry for OPRM1

1. General information

Official gene symbolOPRM1
Entrez ID4988
Gene full nameopioid receptor, mu 1
Other gene symbolsLMOR M-OR-1 MOP MOR MOR1 OPRM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001965G-protein alpha-subunit bindingIDAmolecular_function
GO:0004930G-protein coupled receptor activityISSmolecular_function
GO:0004979Beta-endorphin receptor activityIEA IMPmolecular_function
GO:0005245Voltage-gated calcium channel activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumTAScellular_component
GO:0005794Golgi apparatusTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportISSbiological_process
GO:0006812Cation transportISSbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIEAbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007194Negative regulation of adenylate cyclase activityISSbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007218Neuropeptide signaling pathwayIMPbiological_process
GO:0007268Synaptic transmissionIMPbiological_process
GO:0007600Sensory perceptionNASbiological_process
GO:0007610BehaviorNASbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019233Sensory perception of painISSbiological_process
GO:0030001Metal ion transportISSbiological_process
GO:0033554Cellular response to stressIMPbiological_process
GO:0034220Ion transmembrane transportISSbiological_process
GO:0038047Morphine receptor activityISSmolecular_function
GO:0043950Positive regulation of cAMP-mediated signalingIDAbiological_process
GO:0043951Negative regulation of cAMP-mediated signalingIDAbiological_process
GO:0045019Negative regulation of nitric oxide biosynthetic processIDAbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processIDAbiological_process
GO:0048149Behavioral response to ethanolIMPbiological_process
GO:0050769Positive regulation of neurogenesisISSbiological_process
GO:0050795Regulation of behaviorIMPbiological_process
GO:0051481Negative regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0055085Transmembrane transportISSbiological_process
GO:0061358Negative regulation of Wnt protein secretionIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0070588Calcium ion transmembrane transportISSbiological_process
GO:0072511Divalent inorganic cation transportISSbiological_process
GO:2000310Regulation of N-methyl-D-aspartate selective glutamate receptor activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85387078760.86480250750.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0414092910
GSE13712_SHEARUp0.0839583206
GSE13712_STATICDown-0.0106659831
GSE19018Up0.0176376810
GSE19899_A1Up0.0261485797
GSE19899_A2Down-0.0004853084
PubMed_21979375_A1Down-0.0652501704
PubMed_21979375_A2Up0.0363800295
GSE35957Up0.0497104748
GSE36640Up0.0004585689
GSE54402Up0.0412994869
GSE9593Down-0.0787154743
GSE43922Up0.0050151692
GSE24585Up0.0000812630
GSE37065Up0.0592139954
GSE28863_A1Down-0.0470569238
GSE28863_A2Up0.1218181324
GSE28863_A3Up0.1031468915
GSE28863_A4Up0.0258928129
GSE48662Up0.0551277472

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7a-5pMIMAT0000062NAhsa-let-7a{Western blot}{downregulation by anti-miRNA oligonucleotide}20668208
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.