HCSGD entry for OAS3

1. General information

Official gene symbolOAS3
Entrez ID4940
Gene full name2'-5'-oligoadenylate synthetase 3, 100kDa
Other gene symbolsp100
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00017302'-5'-oligoadenylate synthetase activityIDAmolecular_function
GO:0003725Double-stranded RNA bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006139Nucleobase-containing compound metabolic processTASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0009615Response to virusIDAbiological_process
GO:0016740Transferase activityIEAmolecular_function
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051607Defense response to virusIDA IEAbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060700Regulation of ribonuclease activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01725039700.07343927660.32319565840.5103431626

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0168665362
GSE13712_SHEARUp2.9669318889
GSE13712_STATICUp1.5642104066
GSE19018Up0.1910277739
GSE19899_A1Down-0.1024396893
GSE19899_A2Down-0.5186263562
PubMed_21979375_A1Down-0.9421263367
PubMed_21979375_A2Down-0.6779797657
GSE35957Down-2.2265720062
GSE36640Down-0.4799071708
GSE54402Down-0.5261939980
GSE9593Down-0.2307817461
GSE43922Down-0.2705339488
GSE24585Up1.4372130596
GSE37065Up1.6339988879
GSE28863_A1Up0.1037627914
GSE28863_A2Up1.6129303843
GSE28863_A3Up0.1012394245
GSE28863_A4Up0.0793510258
GSE48662Down-0.0569087758

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.