HCSGD entry for NCF4
1. General information
| Official gene symbol | NCF4 |
|---|---|
| Entrez ID | 4689 |
| Gene full name | neutrophil cytosolic factor 4, 40kDa |
| Other gene symbols | NCF P40PHOX SH3PXD4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0002479 | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007154 | Cell communication | IEA | biological_process |
| GO:0010008 | Endosome membrane | IDA | cellular_component |
| GO:0016020 | Membrane | IDA | cellular_component |
| GO:0016176 | Superoxide-generating NADPH oxidase activator activity | IMP | molecular_function |
| GO:0032010 | Phagolysosome | TAS | cellular_component |
| GO:0032266 | Phosphatidylinositol-3-phosphate binding | IDA | molecular_function |
| GO:0035091 | Phosphatidylinositol binding | IEA | molecular_function |
| GO:0042590 | Antigen processing and presentation of exogenous peptide antigen via MHC class I | TAS | biological_process |
| GO:0043020 | NADPH oxidase complex | IDA | cellular_component |
| GO:0043085 | Positive regulation of catalytic activity | IMP | biological_process |
| GO:0046983 | Protein dimerization activity | TAS | molecular_function |
| GO:0050790 | Regulation of catalytic activity | IMP | biological_process |
| GO:0051701 | Interaction with host | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
| GO:0090382 | Phagosome maturation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5782459937 | 0.7726692451 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0250100198 |
| GSE13712_SHEAR | Down | -0.0125072386 |
| GSE13712_STATIC | Down | -0.0993541199 |
| GSE19018 | Up | 0.1923126219 |
| GSE19899_A1 | Up | 0.0648373157 |
| GSE19899_A2 | Up | 0.2620045622 |
| PubMed_21979375_A1 | Up | 0.0883011843 |
| PubMed_21979375_A2 | Up | 0.0348463780 |
| GSE35957 | Up | 0.3523930215 |
| GSE36640 | Down | -0.0093327112 |
| GSE54402 | Up | 0.0960059022 |
| GSE9593 | Down | -0.0414617902 |
| GSE43922 | Down | -0.1274745020 |
| GSE24585 | Up | 0.1453670702 |
| GSE37065 | Down | -0.0356321616 |
| GSE28863_A1 | Down | -0.1991101493 |
| GSE28863_A2 | Down | -0.1046706535 |
| GSE28863_A3 | Up | 0.1176330054 |
| GSE28863_A4 | Down | -0.0275963485 |
| GSE48662 | Up | 0.1321167123 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dextromethorphan | DB00514 | APRD00655 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017337 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
