HCSGD entry for MEFV

1. General information

Official gene symbolMEFV
Entrez ID4210
Gene full nameMediterranean fever
Other gene symbolsFMF MEF TRIM20
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIDAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005875Microtubule associated complexIDAcellular_component
GO:0006954Inflammatory responseIDAbiological_process
GO:0008270Zinc ion bindingIEA NASmolecular_function
GO:0032691Negative regulation of interleukin-1 beta productionIMPbiological_process
GO:0032695Negative regulation of interleukin-12 productionIMPbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0071641Negative regulation of macrophage inflammatory protein 1 alpha productionIMPbiological_process
GO:2001056Positive regulation of cysteine-type endopeptidase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29092423540.53283743400.98984967051.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0782668368
GSE13712_SHEARDown-0.0504714800
GSE13712_STATICDown-0.0473457016
GSE19018Up0.0335274182
GSE19899_A1Up0.1182920840
GSE19899_A2Up0.1525927838
PubMed_21979375_A1Down-0.3254890695
PubMed_21979375_A2Down-0.4314323899
GSE35957Up0.0896118832
GSE36640Down-0.0516283051
GSE54402Down-0.0114880910
GSE9593Down-0.0682595479
GSE43922Up0.0860335494
GSE24585Down-0.1850748883
GSE37065Up0.3748470002
GSE28863_A1Down-0.1414710350
GSE28863_A2Down-0.0034859033
GSE28863_A3Up0.3518713867
GSE28863_A4Down-0.0016866208
GSE48662Up1.5437962208

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.