HCSGD entry for PDX1

1. General information

Official gene symbolPDX1
Entrez ID3651
Gene full namepancreatic and duodenal homeobox 1
Other gene symbolsGSF IDX-1 IPF1 IUF1 MODY4 PDX-1 STF-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001046Core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001889Liver developmentIEAbiological_process
GO:0003309Type B pancreatic cell differentiationIDA ISSbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006091Generation of precursor metabolites and energyTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0007224Smoothened signaling pathwayIEAbiological_process
GO:0007263Nitric oxide mediated signal transductionIDAbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009611Response to woundingIEAbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0010040Response to iron(II) ionIEAbiological_process
GO:0010157Response to chlorateIEAbiological_process
GO:0010260Organ senescenceIEAbiological_process
GO:0010942Positive regulation of cell deathIEAbiological_process
GO:0016331Morphogenesis of embryonic epitheliumIEAbiological_process
GO:0030073Insulin secretionIDAbiological_process
GO:0031017Exocrine pancreas developmentIEAbiological_process
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032024Positive regulation of insulin secretionIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033273Response to vitaminIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0035094Response to nicotineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043201Response to leucineIEAbiological_process
GO:0043388Positive regulation of DNA bindingIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048565Digestive tract developmentIEAbiological_process
GO:0048863Stem cell differentiationIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051594Detection of glucoseISSbiological_process
GO:0060290TransdifferentiationIEAbiological_process
GO:0070542Response to fatty acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.64716277500.86587305950.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0308912542
GSE13712_SHEARDown-0.0545223430
GSE13712_STATICDown-0.0340448624
GSE19018Up0.0556644667
GSE19899_A1Up0.0567725424
GSE19899_A2Up0.0333311325
PubMed_21979375_A1Down-0.0318673568
PubMed_21979375_A2Down-0.2647431213
GSE35957Up0.2811919399
GSE36640Up0.0160641728
GSE54402Up0.0436945274
GSE9593Up0.0003841618
GSE43922Up0.2379500317
GSE24585Up0.0560963750
GSE37065Up0.0465824689
GSE28863_A1Down-0.0377341626
GSE28863_A2Down-0.0892679493
GSE28863_A3Up0.1850268500
GSE28863_A4Up0.1022347138
GSE48662Down-0.0105654023

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.