HCSGD entry for ACAA1
1. General information
| Official gene symbol | ACAA1 |
|---|---|
| Entrez ID | 30 |
| Gene full name | acetyl-CoA acyltransferase 1 |
| Other gene symbols | ACAA PTHIO THIO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000038 | Very long-chain fatty acid metabolic process | IMP | biological_process |
| GO:0003988 | Acetyl-CoA C-acyltransferase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005782 | Peroxisomal matrix | TAS | cellular_component |
| GO:0006635 | Fatty acid beta-oxidation | IMP | biological_process |
| GO:0008206 | Bile acid metabolic process | IMP | biological_process |
| GO:0016401 | Palmitoyl-CoA oxidase activity | IMP | molecular_function |
| GO:0016747 | Transferase activity, transferring acyl groups other than amino-acyl groups | IEA | molecular_function |
| GO:0033540 | Fatty acid beta-oxidation using acyl-CoA oxidase | TAS | biological_process |
| GO:0033559 | Unsaturated fatty acid metabolic process | TAS | biological_process |
| GO:0036109 | Alpha-linolenic acid metabolic process | TAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1005478819 | 0.8556512936 | 0.6613808846 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6272953880 |
| GSE13712_SHEAR | Down | -0.0561528633 |
| GSE13712_STATIC | Up | 0.2720420527 |
| GSE19018 | Up | 0.0299439947 |
| GSE19899_A1 | Down | -0.0192810630 |
| GSE19899_A2 | Up | 0.7842217053 |
| PubMed_21979375_A1 | Down | -0.1331471905 |
| PubMed_21979375_A2 | Up | 0.5129905373 |
| GSE35957 | Up | 0.2178057441 |
| GSE36640 | Up | 1.0443037285 |
| GSE54402 | Up | 0.0325665101 |
| GSE9593 | Up | 0.2200084497 |
| GSE43922 | Down | -0.1512131609 |
| GSE24585 | Down | -0.0051001499 |
| GSE37065 | Down | -0.0583087983 |
| GSE28863_A1 | Down | -0.0677826586 |
| GSE28863_A2 | Down | -0.1953349890 |
| GSE28863_A3 | Down | -0.1436946600 |
| GSE28863_A4 | Up | 0.0535531908 |
| GSE48662 | Up | 0.1285493030 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Trimetazidine | DB09069 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT036918 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047559 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
