HCSGD entry for GRM4

1. General information

Official gene symbolGRM4
Entrez ID2914
Gene full nameglutamate receptor, metabotropic 4
Other gene symbolsGPRC1D MGLUR4 mGlu4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIDAbiological_process
GO:0004930G-protein coupled receptor activityIEA IMPmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007196Adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathwayIMPbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007612LearningIEAbiological_process
GO:0008066Glutamate receptor activityIMPmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0043410Positive regulation of MAPK cascadeIEPbiological_process
GO:0043523Regulation of neuron apoptotic processTASbiological_process
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0048787Presynaptic active zone membraneIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46440101440.76960518220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2438523172
GSE13712_SHEARUp0.1752148908
GSE13712_STATICUp0.1667615216
GSE19018Down-0.0527115836
GSE19899_A1Up0.0108197963
GSE19899_A2Up0.0543532978
PubMed_21979375_A1Up0.1157722337
PubMed_21979375_A2Down-0.2028117799
GSE35957Up0.0273706899
GSE36640Down-0.0148502854
GSE54402Up0.0564791531
GSE9593Down-0.1186421121
GSE43922Up0.1489533097
GSE24585Up0.1800212420
GSE37065Down-0.0842285971
GSE28863_A1Up0.0839092051
GSE28863_A2Up0.3952704621
GSE28863_A3Up0.1731023964
GSE28863_A4Down-0.0883851703
GSE48662Up0.2215093917

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.