HCSGD entry for LAMTOR2
1. General information
| Official gene symbol | LAMTOR2 |
|---|---|
| Entrez ID | 28956 |
| Gene full name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 |
| Other gene symbols | ENDAP HSPC003 MAPBPIP MAPKSP1AP ROBLD3 Ragulator2 p14 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IEA | biological_process |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005770 | Late endosome | ISS | cellular_component |
| GO:0016049 | Cell growth | IMP | biological_process |
| GO:0032008 | Positive regulation of TOR signaling | IMP | biological_process |
| GO:0032947 | Protein complex scaffold | IDA | molecular_function |
| GO:0034613 | Cellular protein localization | IMP | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0071230 | Cellular response to amino acid stimulus | IMP | biological_process |
| GO:0071986 | Ragulator complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2974001710 | 0.5146423350 | 0.9965545570 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4936451516 |
| GSE13712_SHEAR | Down | -0.0469606131 |
| GSE13712_STATIC | Up | 0.0586953697 |
| GSE19018 | Up | 0.0229280137 |
| GSE19899_A1 | Up | 0.2504140529 |
| GSE19899_A2 | Up | 0.1910738198 |
| PubMed_21979375_A1 | Up | 0.5838849438 |
| PubMed_21979375_A2 | Down | -0.1812148583 |
| GSE35957 | Down | -0.3045665443 |
| GSE36640 | Up | 0.3071396798 |
| GSE54402 | Up | 0.1581047754 |
| GSE9593 | Up | 0.0579037553 |
| GSE43922 | Up | 0.1031005887 |
| GSE24585 | Down | -0.0746510120 |
| GSE37065 | Down | -0.0925181295 |
| GSE28863_A1 | Down | -0.2772320647 |
| GSE28863_A2 | Down | -0.1178750734 |
| GSE28863_A3 | Down | -0.3515854356 |
| GSE28863_A4 | Down | -0.1711678932 |
| GSE48662 | Up | 0.2982640645 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT005438 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040283 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
