HCSGD entry for GRIA1

1. General information

Official gene symbolGRIA1
Entrez ID2890
Gene full nameglutamate receptor, ionotropic, AMPA 1
Other gene symbolsGLUH1 GLUR1 GLURA GluA1 HBGR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004971Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityIDAmolecular_function
GO:0005234Extracellular-glutamate-gated ion channel activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0008021Synaptic vesicleIEAcellular_component
GO:0008066Glutamate receptor activityTASmolecular_function
GO:0009986Cell surfaceISScellular_component
GO:0014069Postsynaptic densityISScellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030165PDZ domain bindingISSmolecular_function
GO:0030425DendriteISScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031623Receptor internalizationIEAbiological_process
GO:0032281Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complexISScellular_component
GO:0032590Dendrite membraneIEAcellular_component
GO:0034220Ion transmembrane transportIDAbiological_process
GO:0035235Ionotropic glutamate receptor signaling pathwayIDAbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0043197Dendritic spineISScellular_component
GO:0044309Neuron spineISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0055085Transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13629104520.90189794460.74494221351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1115204444
GSE13712_SHEARDown-0.0336818459
GSE13712_STATICUp0.0619282309
GSE19018Down-0.1346665411
GSE19899_A1Up0.0480103115
GSE19899_A2Up0.1104807576
PubMed_21979375_A1Down-0.0856331094
PubMed_21979375_A2Up0.1831024162
GSE35957Down-0.1896406262
GSE36640Down-0.0606947985
GSE54402Up0.0254622531
GSE9593Up0.0596305534
GSE43922Up0.0125365483
GSE24585Up0.0086469877
GSE37065Down-0.1374268489
GSE28863_A1Up0.8189431335
GSE28863_A2Up1.4400116135
GSE28863_A3Up0.3307048974
GSE28863_A4Up0.1098683024
GSE48662Down-0.1314595872

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027
EnfluraneDB00228 APRD00234
IsofluraneDB00753 APRD00212
MethoxyfluraneDB01028 APRD00744
DesfluraneDB01189 APRD00907
SevofluraneDB01236 APRD00219
TalampanelDB04982 -
CX717DB05047 -
PerampanelDB08883 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004156MicroarrayFunctional MTI (Weak)16822819
hsa-miR-335-5pMIMAT0000765MIRT018501MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.