HCSGD entry for GRB2

1. General information

Official gene symbolGRB2
Entrez ID2885
Gene full namegrowth factor receptor-bound protein 2
Other gene symbolsASH EGFRBP-GRB2 Grb3-3 MST084 MSTP084 NCKAP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0005070SH3/SH2 adaptor activityIEA TASmolecular_function
GO:0005154Epidermal growth factor receptor bindingIPImolecular_function
GO:0005168Neurotrophin TRKA receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008180COP9 signalosomeIDA IEAcellular_component
GO:0008286Insulin receptor signaling pathwayIPI TASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0012506Vesicle membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0017124SH3 domain bindingIDAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030838Positive regulation of actin filament polymerizationIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0031623Receptor internalizationIMPbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0042770Signal transduction in response to DNA damageIMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043408Regulation of MAPK cascadeIEAbiological_process
GO:0043560Insulin receptor substrate bindingIEA IPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisIEAbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0060670Branching involved in labyrinthine layer morphogenesisIEAbiological_process
GO:0070436Grb2-EGFR complexIDAcellular_component
GO:0071479Cellular response to ionizing radiationIMPbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01220264430.98965657080.27579828331.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1447681361
GSE13712_SHEARUp0.5308002149
GSE13712_STATICUp0.5303055209
GSE19018Up0.2396525989
GSE19899_A1Up0.3674415069
GSE19899_A2Up0.6630293794
PubMed_21979375_A1Up1.0729305063
PubMed_21979375_A2Up1.1673471455
GSE35957Up0.0081092897
GSE36640Up0.5596258137
GSE54402Up0.4179330021
GSE9593Up0.0167153895
GSE43922Up0.3194204318
GSE24585Up0.3915853857
GSE37065Down-0.0884088434
GSE28863_A1Down-0.1422769448
GSE28863_A2Up0.2409495845
GSE28863_A3Down-0.4329075603
GSE28863_A4Up0.1186212223
GSE48662Down-0.1090443666

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Pegademase bovineDB00061 BTD00100 | BIOD00100
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic AcidDB03276 EXPT01283

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-433-3pMIMAT0001627MIRT001201Luciferase reporter assay//Western blotFunctional MTI19531230
hsa-miR-378a-3pMIMAT0000732MIRT007278Luciferase reporter assayFunctional MTI23447532
hsa-miR-124-3pMIMAT0000422MIRT022221MicroarrayFunctional MTI (Weak)18668037
hsa-miR-34a-5pMIMAT0000255MIRT025255SequencingFunctional MTI (Weak)20371350
hsa-miR-7-5pMIMAT0000252MIRT025709SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT027965SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031431ProteomicsFunctional MTI (Weak)18668040
hsa-miR-92b-3pMIMAT0003218MIRT040690CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048495CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21113463Cell transfection with anti-E6 and anti-E7 short interfering RNA moderately reduced the expression of mRNA for CDC25C, GRB2, GTSE1, and PLK1 genes and induced expression of CDKN1A (p21(CIP)) gene mRNA
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