HCSGD entry for LAT

1. General information

Official gene symbolLAT
Entrez ID27040
Gene full namelinker for activation of T cells
Other gene symbolsLAT1 pp36
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001772Immunological synapseIDA IEAcellular_component
GO:0005070SH3/SH2 adaptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIDAbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIDAbiological_process
GO:0007265Ras protein signal transductionIMPbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008180COP9 signalosomeIEA ISScellular_component
GO:0009967Positive regulation of signal transductionIDAbiological_process
GO:0010467Gene expressionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0019722Calcium-mediated signalingIMPbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042629Mast cell granuleIEAcellular_component
GO:0043303Mast cell degranulationIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045121Membrane raftTAScellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050863Regulation of T cell activationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07206219370.97796133130.57178409161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1117323141
GSE13712_SHEARUp0.3170419054
GSE13712_STATICUp0.1856445392
GSE19018Up0.1025544712
GSE19899_A1Up0.0866508124
GSE19899_A2Up0.3573615501
PubMed_21979375_A1Up0.9706731662
PubMed_21979375_A2Up0.6612414400
GSE35957Down-0.0491943478
GSE36640Up1.0366599194
GSE54402Down-0.1455552130
GSE9593Down-0.0607464068
GSE43922Up0.3550289850
GSE24585Down-0.1109086415
GSE37065Down-0.0436759953
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.1441762205

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.