HCSGD entry for GAB1
1. General information
| Official gene symbol | GAB1 |
|---|---|
| Entrez ID | 2549 |
| Gene full name | GRB2-associated binding protein 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | IEA TAS | biological_process |
| GO:0007257 | Activation of JUN kinase activity | IEA | biological_process |
| GO:0007507 | Heart development | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008544 | Epidermis development | IEA | biological_process |
| GO:0030334 | Regulation of cell migration | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048008 | Platelet-derived growth factor receptor signaling pathway | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0060711 | Labyrinthine layer development | IEA | biological_process |
| GO:0070102 | Interleukin-6-mediated signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9747202310 | 0.0454611717 | 0.9999902473 | 0.4004980254 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3622707225 |
| GSE13712_SHEAR | Down | -0.4986035956 |
| GSE13712_STATIC | Down | -1.1332870799 |
| GSE19018 | Up | 0.1369331367 |
| GSE19899_A1 | Down | -0.1869021723 |
| GSE19899_A2 | Down | -0.6369764713 |
| PubMed_21979375_A1 | Down | -0.1719239703 |
| PubMed_21979375_A2 | Down | -0.2823292011 |
| GSE35957 | Down | -0.1606996812 |
| GSE36640 | Down | -0.1807968468 |
| GSE54402 | Down | -0.2788096176 |
| GSE9593 | Up | 0.1251135505 |
| GSE43922 | Down | -0.2617345965 |
| GSE24585 | Up | 0.2022190405 |
| GSE37065 | Up | 0.1375682788 |
| GSE28863_A1 | Up | 0.1294535645 |
| GSE28863_A2 | Down | -0.0126387853 |
| GSE28863_A3 | Up | 0.0557380439 |
| GSE28863_A4 | Down | -0.1337316847 |
| GSE48662 | Down | -0.0389507147 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181d-5p | MIMAT0002821 | MIRT041177 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
