HCSGD entry for CYP24A1


1. General information

Official gene symbolCYP24A1
Entrez ID1591
Gene full namecytochrome P450, family 24, subfamily A, polypeptide 1
Other gene symbolsCP24 CYP24 HCAI P450-CC24
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationIEPbiological_process
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005743Mitochondrial inner membraneTAScellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:000840325-hydroxycholecalciferol-24-hydroxylase activityIEAmolecular_function
GO:0016491Oxidoreductase activityNASmolecular_function
GO:0020037Heme bindingTASmolecular_function
GO:00303421-alpha,25-dihydroxyvitamin D3 24-hydroxylase activityIDAmolecular_function
GO:0033280Response to vitamin DIDAbiological_process
GO:0042359Vitamin D metabolic processTASbiological_process
GO:0042369Vitamin D catabolic processNASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070561Vitamin D receptor signaling pathwayNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09147242510.93655702670.63643819721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0200315635
GSE13712_SHEARDown-0.0119995294
GSE13712_STATICDown-0.0683307322
GSE19018Up0.1899225389
GSE19899_A1Up0.1550957638
GSE19899_A2Up0.2801453511
PubMed_21979375_A1Up0.3549491786
PubMed_21979375_A2Up0.1270985860
GSE35957Up0.0688164237
GSE36640Up0.1218027609
GSE54402Up0.1818012372
GSE9593Down-0.1831824924
GSE43922Up0.0171295148
GSE24585Down-0.0480632013
GSE37065Up1.7243172498
GSE28863_A1Up0.4169328625
GSE28863_A2Up0.5826955020
GSE28863_A3Up0.0871909685
GSE28863_A4Down-0.1141283098
GSE48662Down-0.0502309832

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

CTA018DB05024 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT004408qRT-PCR//Luciferase reporter assay//Western blot//Northern blot//Reporter assayFunctional MTI19570947
hsa-miR-215-5pMIMAT0000272MIRT024646MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026473MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT029534MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.