HCSGD entry for CYP3A5

1. General information

Official gene symbolCYP3A5
Entrez ID1577
Gene full namecytochrome P450, family 3, subfamily A, polypeptide 5
Other gene symbolsCP35 CYPIIIA5 P450PCN3 PCN3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityISSmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0009822Alkaloid catabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0019825Oxygen bindingTASmolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0042737Drug catabolic processIDAbiological_process
GO:0043231Intracellular membrane-bounded organelleTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0070330Aromatase activityIEAmolecular_function
GO:0070989Oxidative demethylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07721952050.98639333610.58674797921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1164897397
GSE13712_SHEARUp0.0325513125
GSE13712_STATICDown-0.0751879232
GSE19018Up0.1028027531
GSE19899_A1Up0.2139058311
GSE19899_A2Up0.4065918362
PubMed_21979375_A1Up0.3855106776
PubMed_21979375_A2Up0.1075033046
GSE35957Up0.2080087878
GSE36640Up0.1118835079
GSE54402Up0.6262514827
GSE9593Up0.0890802519
GSE43922Up0.8241947283
GSE24585Up0.0633452890
GSE37065Up0.1248914754
GSE28863_A1Down-0.0146594984
GSE28863_A2Down-0.0804866663
GSE28863_A3Up0.1334466964
GSE28863_A4Up0.0387710039
GSE48662Up0.0413844510

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliperidoneDB01267 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017425MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.