HCSGD entry for ADCY3

1. General information

Official gene symbolADCY3
Entrez ID109
Gene full nameadenylate cyclase 3
Other gene symbolsAC3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0004016Adenylate cyclase activityIEAmolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005929CiliumIEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007608Sensory perception of smellIEAbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009190Cyclic nucleotide biosynthetic processIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016849Phosphorus-oxygen lyase activityIEAmolecular_function
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97965703430.00094600890.99999024730.0579451163

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3750359290
GSE13712_SHEARUp0.1045770781
GSE13712_STATICUp0.0993288613
GSE19018Down-0.4822239454
GSE19899_A1Down-0.3733175290
GSE19899_A2Down-1.7140867601
PubMed_21979375_A1Down-1.1039759363
PubMed_21979375_A2Down-1.0736401184
GSE35957Down-0.1442040510
GSE36640Down-2.1350103082
GSE54402Down-0.4574640241
GSE9593Down-0.5294865599
GSE43922Down-0.9033129234
GSE24585Down-1.2762361186
GSE37065Down-0.2575077010
GSE28863_A1Up0.3521321704
GSE28863_A2Up0.4250229723
GSE28863_A3Down-0.2798611804
GSE28863_A4Down-0.2167148402
GSE48662Down-0.1950249237

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022973MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1301-3pMIMAT0005797MIRT035974CLASHFunctional MTI (Weak)23622248
hsa-miR-1296-5pMIMAT0005794MIRT036106CLASHFunctional MTI (Weak)23622248
hsa-miR-877-5pMIMAT0004949MIRT037340CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.