HCSGD entry for THOC1
1. General information
| Official gene symbol | THOC1 |
|---|---|
| Entrez ID | 9984 |
| Gene full name | THO complex 1 |
| Other gene symbols | HPR1 P84 P84N5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000018 | Regulation of DNA recombination | IMP | biological_process |
| GO:0000346 | Transcription export complex | IDA | cellular_component |
| GO:0000347 | THO complex | IDA | cellular_component |
| GO:0000445 | THO complex part of transcription export complex | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0006397 | MRNA processing | IEA | biological_process |
| GO:0006406 | MRNA export from nucleus | IDA IMP | biological_process |
| GO:0006915 | Apoptotic process | IDA | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0008380 | RNA splicing | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031297 | Replication fork processing | IMP | biological_process |
| GO:0032784 | Regulation of DNA-templated transcription, elongation | IDA | biological_process |
| GO:0032786 | Positive regulation of DNA-templated transcription, elongation | IMP | biological_process |
| GO:0046784 | Viral mRNA export from host cell nucleus | IDA | biological_process |
| GO:0048297 | Negative regulation of isotype switching to IgA isotypes | ISS | biological_process |
| GO:2000002 | Negative regulation of DNA damage checkpoint | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9038327913 | 0.0283361726 | 0.9999902473 | 0.3205001287 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0796200804 |
| GSE13712_SHEAR | Up | 0.0275580053 |
| GSE13712_STATIC | Down | -0.0790472026 |
| GSE19018 | Down | -0.8733636357 |
| GSE19899_A1 | Up | 0.0836990710 |
| GSE19899_A2 | Down | -0.5497540070 |
| PubMed_21979375_A1 | Up | 1.2143369591 |
| PubMed_21979375_A2 | Down | -0.0639045310 |
| GSE35957 | Down | -0.8159579943 |
| GSE36640 | Down | -1.2545883115 |
| GSE54402 | Up | 0.1676391519 |
| GSE9593 | Down | -0.6685520353 |
| GSE43922 | Up | 0.2305248990 |
| GSE24585 | Down | -0.3788949819 |
| GSE37065 | Up | 0.0988758879 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2929216823 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045303 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
