HCSGD entry for RBX1

1. General information

Official gene symbolRBX1
Entrez ID9978
Gene full namering-box 1, E3 ubiquitin protein ligase
Other gene symbolsBA554C12.1 RNF75 ROC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolISS TAScellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006513Protein monoubiquitinationIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016032Viral processTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0019005SCF ubiquitin ligase complexIDA ISScellular_component
GO:0019788NEDD8 ligase activityIDAmolecular_function
GO:0030891VCB complexIEAcellular_component
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic processIDA ISSbiological_process
GO:0031461Cullin-RING ubiquitin ligase complexIDAcellular_component
GO:0031462Cul2-RING ubiquitin ligase complexIDAcellular_component
GO:0031463Cul3-RING ubiquitin ligase complexIDAcellular_component
GO:0031464Cul4A-RING ubiquitin ligase complexIDAcellular_component
GO:0031465Cul4B-RING ubiquitin ligase complexIDAcellular_component
GO:0031466Cul5-RING ubiquitin ligase complexIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIDAmolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0045116Protein neddylationIDAbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72397769840.17686363740.99999024730.8138510140

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2088730304
GSE13712_SHEARDown-0.0490155532
GSE13712_STATICUp0.0000719121
GSE19018Up0.6394396571
GSE19899_A1Up0.0392576781
GSE19899_A2Down-0.2727149978
PubMed_21979375_A1Up0.2087739502
PubMed_21979375_A2Down-0.1342201028
GSE35957Down-0.2763190831
GSE36640Down-0.7518798108
GSE54402Down-0.0064767924
GSE9593Down-0.2383835030
GSE43922Down-0.1244779819
GSE24585Down-0.1048180750
GSE37065Up0.1943767901
GSE28863_A1Down-0.0410665976
GSE28863_A2Down-0.1440098570
GSE28863_A3Down-0.2133880447
GSE28863_A4Up0.1557517837
GSE48662Up0.0558545417

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92a-3pMIMAT0000092MIRT049206CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22965024Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis
22965024RBX1/ROC1 is an essential subunit of the largest multiunit Cullin-RING E3 ligase (CRL), which controls the degradation of diverse substrates, thereby regulating numerous cellular processes
22965024Moreover, siRNA silencing of RBX1 inhibits the proliferation of liver cancer cells both in vitro and in vivo by inducing CDKN1A/p21-dependent cell senescence
22965024Interestingly, independent of senescence, RBX1 knockdown also triggers an autophagy response, due, at least in part, to the accumulation of the MTOR-inhibitory protein DEPTOR, a recently identified CRL substrate
22965024Biologically, blockage of autophagy significantly enhances the growth-suppressive effect of RBX1 knockdown by triggering massive apoptosis, indicating that the autophagy response upon RBX1 knockdown serves as a survival signal in liver cells
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