HCSGD entry for CDC34
1. General information
| Official gene symbol | CDC34 |
|---|---|
| Entrez ID | 997 |
| Gene full name | cell division cycle 34 |
| Other gene symbols | E2-CDC34 UBC3 UBCH3 UBE2R1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | NAS | biological_process |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006270 | DNA replication initiation | NAS | biological_process |
| GO:0006464 | Cellular protein modification process | NAS | biological_process |
| GO:0016567 | Protein ubiquitination | IDA NAS | biological_process |
| GO:0016881 | Acid-amino acid ligase activity | IEA | molecular_function |
| GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0043525 | Positive regulation of neuron apoptotic process | IEA | biological_process |
| GO:0043951 | Negative regulation of cAMP-mediated signaling | IDA | biological_process |
| GO:0070848 | Response to growth factor | IEA | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
| GO:0090261 | Positive regulation of inclusion body assembly | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0455438851 | 0.8862474868 | 0.4740057730 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2838851830 |
| GSE13712_SHEAR | Down | -0.0032970997 |
| GSE13712_STATIC | Up | 0.0693027181 |
| GSE19018 | Up | 0.0275109824 |
| GSE19899_A1 | Up | 0.4536612385 |
| GSE19899_A2 | Up | 0.9318556566 |
| PubMed_21979375_A1 | Up | 0.5508486283 |
| PubMed_21979375_A2 | Up | 0.7283077433 |
| GSE35957 | Down | -0.1915811643 |
| GSE36640 | Up | 0.3847732871 |
| GSE54402 | Up | 0.3858284494 |
| GSE9593 | Down | -0.0725027413 |
| GSE43922 | Up | 0.7616880773 |
| GSE24585 | Down | -0.1431534388 |
| GSE37065 | Down | -0.1438441229 |
| GSE28863_A1 | Down | -0.1553717904 |
| GSE28863_A2 | Down | -0.4099015729 |
| GSE28863_A3 | Down | -0.0956793213 |
| GSE28863_A4 | Up | 0.0978167592 |
| GSE48662 | Up | 0.3188799520 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001229 | Luciferase reporter assay//Western blot | Functional MTI | 19126550 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001229 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027687 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039748 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041675 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
