HCSGD entry for MED13
1. General information
| Official gene symbol | MED13 |
|---|---|
| Entrez ID | 9969 |
| Gene full name | mediator complex subunit 13 |
| Other gene symbols | ARC250 DRIP250 HSPC221 THRAP1 TRAP240 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IDA | molecular_function |
| GO:0003712 | Transcription cofactor activity | IDA | molecular_function |
| GO:0003713 | Transcription coactivator activity | IDA | molecular_function |
| GO:0004872 | Receptor activity | IDA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IDA TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016592 | Mediator complex | IDA | cellular_component |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | NAS | molecular_function |
| GO:0030518 | Intracellular steroid hormone receptor signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0042809 | Vitamin D receptor binding | NAS | molecular_function |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046966 | Thyroid hormone receptor binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1549792371 | 0.6696552525 | 0.7823568278 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1666349290 |
| GSE13712_SHEAR | Up | 0.5175548934 |
| GSE13712_STATIC | Up | 0.3645314666 |
| GSE19018 | Down | -0.0926557585 |
| GSE19899_A1 | Down | -0.0381947089 |
| GSE19899_A2 | Down | -0.1802354458 |
| PubMed_21979375_A1 | Down | -0.1064271250 |
| PubMed_21979375_A2 | Down | -0.0581309050 |
| GSE35957 | Up | 0.0448404662 |
| GSE36640 | Down | -0.1408209899 |
| GSE54402 | Up | 0.0280125606 |
| GSE9593 | Down | -0.0790067086 |
| GSE43922 | Down | -0.0854443273 |
| GSE24585 | Up | 0.6381944035 |
| GSE37065 | Up | 0.2565634807 |
| GSE28863_A1 | Up | 0.5890395049 |
| GSE28863_A2 | Up | 0.5473236886 |
| GSE28863_A3 | Down | -0.5594897719 |
| GSE28863_A4 | Up | 0.1144961976 |
| GSE48662 | Up | 0.1687545601 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-208a-3p | MIMAT0000241 | MIRT003912 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 17379774 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT019505 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027154 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031923 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031923 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1303 | MIMAT0005891 | MIRT035880 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047970 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048177 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050942 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052192 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
