HCSGD entry for USP3
1. General information
| Official gene symbol | USP3 |
|---|---|
| Entrez ID | 9960 |
| Gene full name | ubiquitin specific peptidase 3 |
| Other gene symbols | SIH003 UBP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | IMP | biological_process |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | TAS | molecular_function |
| GO:0006281 | DNA repair | IMP | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016578 | Histone deubiquitination | IDA | biological_process |
| GO:0016787 | Hydrolase activity | IEA | molecular_function |
| GO:0031647 | Regulation of protein stability | IDA | biological_process |
| GO:0042393 | Histone binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1303730785 | 0.4403976673 | 0.7333577991 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1216276017 |
| GSE13712_SHEAR | Down | -0.5681779570 |
| GSE13712_STATIC | Down | -0.0704103344 |
| GSE19018 | Down | -0.0202834128 |
| GSE19899_A1 | Up | 0.3295602442 |
| GSE19899_A2 | Up | 0.4534847931 |
| PubMed_21979375_A1 | Up | 1.5207740209 |
| PubMed_21979375_A2 | Up | 0.4218721629 |
| GSE35957 | Down | -0.1720799943 |
| GSE36640 | Down | -0.5600075957 |
| GSE54402 | Up | 0.7131827496 |
| GSE9593 | Up | 0.1322766632 |
| GSE43922 | Up | 0.1523990065 |
| GSE24585 | Down | -0.6155777813 |
| GSE37065 | Down | -0.0748920947 |
| GSE28863_A1 | Up | 0.3747162730 |
| GSE28863_A2 | Up | 0.0874003880 |
| GSE28863_A3 | Down | -0.2590638360 |
| GSE28863_A4 | Up | 0.0201463786 |
| GSE48662 | Down | -0.4262433810 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027446 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028943 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040763 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047466 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
