HCSGD entry for USP15
1. General information
| Official gene symbol | USP15 |
|---|---|
| Entrez ID | 9958 |
| Gene full name | ubiquitin specific peptidase 15 |
| Other gene symbols | UNPH-2 UNPH4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004197 | Cysteine-type endopeptidase activity | IMP | molecular_function |
| GO:0004221 | Ubiquitin thiolesterase activity | IDA IEA | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005160 | Transforming growth factor beta receptor binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IDA IMP TAS | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0016579 | Protein deubiquitination | IDA | biological_process |
| GO:0030509 | BMP signaling pathway | IDA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0035520 | Monoubiquitinated protein deubiquitination | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0046332 | SMAD binding | IPI | molecular_function |
| GO:0060389 | Pathway-restricted SMAD protein phosphorylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9223489267 | 0.4902357091 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.1158475323 |
| GSE28863_A2 | Down | -0.3369024399 |
| GSE28863_A3 | Down | -0.4888837362 |
| GSE28863_A4 | Up | 0.2020121555 |
| GSE48662 | Up | 0.2707133548 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027211 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031860 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032405 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045575 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046709 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27160904 | Here, we show that OIS-associated transcriptional downregulation of deubiquitinating enzyme USP1 triggers and maintains a DNA damage checkpoint response with atypical DNA lesions that is dependent on functional FANCD2-FI-ATR-CHK1-p53-CDKN1A signaling |
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